Cnnm3 cyclin M3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnnm3provided by MGI
Official Full Name: cyclin M3provided by MGI
Primary source: MGI:MGI:2151055
See related: Ensembl:ENSMUSG00000001138 AllianceGenome:MGI:2151055
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Clp3; Acdp3; mACDP3
Summary: Predicted to enable transmembrane transporter activity. Predicted to be involved in magnesium ion homeostasis. Predicted to be active in plasma membrane. Orthologous to human CNNM3 (cyclin and CBS domain divalent metal cation transport mediator 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 14.2), thymus adult (RPKM 11.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 15.3 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (36550948..36567318)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (36511867..36528237)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Oncogenic PRL-2 controls tumor growth by modulating intracellular magnesium levels through binding with the CNNM3 magnesium transporter.
Title: The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in magnesium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in magnesium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: metal transporter CNNM3

Names: ancient conserved domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039551.2 → NP_001034640.1 metal transporter CNNM3 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC084391, BC080275

Consensus CDS

CCDS14881.1

UniProtKB/Swiss-Prot

Q32NY4

Related

ENSMUSP00000095383.4, ENSMUST00000097776.4

Conserved Domains (1) summary

cd04590
Location:329 → 449

CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...
NM_001331209.1 → NP_001318138.1 metal transporter CNNM3 isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC084391, BC052714, BC058426, BC080275

UniProtKB/Swiss-Prot

Q32NY4
NM_053186.3 → NP_444416.2 metal transporter CNNM3 isoform 1 precursor

See identical proteins and their annotated locations for NP_444416.2

Status: VALIDATED

Source sequence(s)

AC084391, AF216964, BC080275

Consensus CDS

CCDS14880.1

UniProtKB/Swiss-Prot

A3KML7, Q32NY4, Q3UFE5, Q7TSZ4, Q8C342, Q9JIM6

Related

ENSMUSP00000001166.8, ENSMUST00000001166.14

Conserved Domains (1) summary

cd04590
Location:329 → 449

CBS_pair_CorC_HlyC_assoc; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in ...