Dgkk diacylglycerol kinase kappa [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dgkkprovided by MGI
Official Full Name: diacylglycerol kinase kappaprovided by MGI
Primary source: MGI:MGI:3580254
See related: Ensembl:ENSMUSG00000062393 AllianceGenome:MGI:3580254
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm360
Summary: Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in glycerolipid metabolic process; intracellular signal transduction; and response to oxidative stress. Predicted to be active in plasma membrane. Is expressed in central nervous system; external genitalia; genital tubercle epithelium; lung; and urethra. Orthologous to human DGKK (diacylglycerol kinase kappa). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: This gene aligns across a gap in the GRCm38 reference genome assembly, and therefore, the 5' end of this gene was annotated on NT_039699.8 and the 3' end was annotated on NT_039700.8 in NCBI's Mus Musculus Annotation Release 105. [15 Jun 2015]
Expression: Biased expression in CNS E18 (RPKM 1.2), CNS E14 (RPKM 0.6) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 3.07 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (6691103..6814602)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (6779306..6948363)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Extracellular vesicles derived from CD4[+] T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation.
Title: Extracellular vesicles derived from CD4(+) T cells carry DGKK to promote sepsis-induced lung injury by regulating oxidative stress and inflammation.
Overexpression of Dgkkappa in neurons is able to rescue the dendritic spine defects of the Fragile X Mental Retardation 1 gene KO neurons.
Title: Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

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Markers

px-23b12 (e-PCR)
- UniSTS:257427

px-56h10 (e-PCR)
- UniSTS:257944

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP-dependent diacylglycerol kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent diacylglycerol kinase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in diacylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diacylglycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphatidic acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to oxidative stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: diacylglycerol kinase kappa

NP_808582.3

EC 2.7.1.107

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177914.3 → NP_808582.3 diacylglycerol kinase kappa

Status: VALIDATED

Source sequence(s)

AL671962, AW121906, BC075627

Consensus CDS

CCDS85745.1

UniProtKB/TrEMBL

Q6DIC8

Related

ENSMUSP00000123079.3, ENSMUST00000145302.3

Conserved Domains (5) summary

smart00046
Location:336 → 458

DAGKc; Diacylglycerol kinase catalytic domain (presumed)

cd00029
Location:170 → 219

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

cd13274
Location:60 → 154

PH_DGK_type2; Type 2 Diacylglycerol kinase Pleckstrin homology (PH) domain

pfam00169
Location:59 → 147

PH; PH domain

cl02440
Location:703 → 860

DAGK_acc; Diacylglycerol kinase accessory domain