Parp12 poly (ADP-ribose) polymerase family, member 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Parp12provided by MGI
Official Full Name: poly (ADP-ribose) polymerase family, member 12provided by MGI
Primary source: MGI:MGI:2143990
See related: Ensembl:ENSMUSG00000038507 AllianceGenome:MGI:2143990
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARTD12; PARP-12; Zc3hdc1; 9930021O16
Summary: Predicted to enable NAD+-protein poly-ADP-ribosyltransferase activity. Predicted to be involved in protein auto-ADP-ribosylation. Predicted to be active in nucleus. Is expressed in early conceptus; gallbladder; genitourinary system; and gut. Orthologous to human PARP12 (poly(ADP-ribose) polymerase family member 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in small intestine adult (RPKM 28.4), colon adult (RPKM 27.7) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B1; 6 17.85 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (39063346..39095283, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (39086412..39118349, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner.
Title: PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner.
PARP12 regulates mouse oocyte meiotic maturation.
Title: PARP12 regulates mouse oocyte meiotic maturation.
To screen for antiviral IFN-stimulated genes that restricted Zika virus replication, and identified PARP12 as a strong inhibitor of Zika virus replication. Findings suggest that PARP12 mediated the ADP-ribosylation of NS1 and NS3, nonstructural viral proteins that are involved in viral replication and modulating host defense responses.
Title: PARP12 suppresses Zika virus infection through PARP-dependent degradation of NS1 and NS3 viral proteins.
PARP12 is an interferon-induced gene with a potential role in cellular defenses against viral infections.
Title: PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125836 (e-PCR)
- UniSTS:162580

RH124286 (e-PCR)
- UniSTS:161108

D6Bwg16e (e-PCR), detects polymorphism
- UniSTS:142577

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein-cysteine ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP12

Names: ADP-ribosyltransferase diphtheria toxin-like 12; poly ADP-ribose polymerase 12; poly [ADP-ribose] polymerase 12; zinc finger CCCH domain-containing protein 1; zinc finger CCCH type domain containing 1

NP_766481.2

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172893.3 → NP_766481.2 protein mono-ADP-ribosyltransferase PARP12

See identical proteins and their annotated locations for NP_766481.2

Status: VALIDATED

Source sequence(s)

AK036886, BC048927, BC120733

Consensus CDS

CCDS20019.1

UniProtKB/Swiss-Prot

Q0VB94, Q80VL6, Q8BZ20, Q8K333, Q8R3U2

UniProtKB/TrEMBL

Q3U0S1

Related

ENSMUSP00000039704.7, ENSMUST00000038398.7

Conserved Domains (5) summary

smart00356
Location:186 → 208

ZnF_C3H1; zinc finger

cd01439
Location:571 → 687

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

pfam00644
Location:506 → 689

PARP; Poly(ADP-ribose) polymerase catalytic domain

pfam02825
Location:387 → 468

WWE; WWE domain

cl02729
Location:309 → 382

WWE; WWE domain