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    Senp3 SUMO/sentrin specific peptidase 3 [ Mus musculus (house mouse) ]

    Gene ID: 80886, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Senp3provided by MGI
    Official Full Name
    SUMO/sentrin specific peptidase 3provided by MGI
    Primary source
    MGI:MGI:2158736
    See related
    Ensembl:ENSMUSG00000005204 AllianceGenome:MGI:2158736
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Smt3ip; Smt3ip1
    Summary
    Enables cysteine-type deubiquitinase activity. Predicted to be involved in negative regulation of double-strand break repair via homologous recombination and protein desumoylation. Located in nucleolus. Is expressed in cerebral cortex and heart. Orthologous to human SENP3 (SUMO specific peptidase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 28.8), CNS E18 (RPKM 23.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Senp3 in Genome Data Viewer
    Location:
    11 B3; 11 42.86 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69563936..69572910, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69673110..69682084, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A1 Neighboring gene predicted gene, 25835 Neighboring gene STARR-positive B cell enhancer ABC_E8419 Neighboring gene predicted gene, 22988 Neighboring gene STARR-positive B cell enhancer ABC_E734 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13, opposite strand Neighboring gene tumor necrosis factor (ligand) superfamily, membrane-bound member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 13 Neighboring gene tumor necrosis factor (ligand) superfamily, member 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SENP3 in monocytes/macrophages up-regulates tissue factor and mediates lipopolysaccharide-induced acute lung injury by enhancing JNK phosphorylation. Chen X, et al. J Cell Mol Med, 2020 May. PMID 32237051, Free PMC Article
    2. Expression and Cell Distribution of SENP3 in Brain Tissue After Traumatic Brain Injury in Mice: A Pilot Study. Yu Z, et al. Cell Mol Neurobiol, 2015 Jul. PMID 25772139
    3. SENP3 facilitates M1 macrophage polarization via the HIF-1α/PKM2 axis in lipopolysaccharide-induced acute lung injury. He S, et al. Innate Immun, 2023 Jan. PMID 37016838, Free PMC Article
    4. SENP3 protects H9C2 cells from apoptosis triggered by H/R via STAT3 pathway. Zhang Y, et al. Eur Rev Med Pharmacol Sci, 2018 May. PMID 29771430
    5. Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity. Hu G, et al. Cell Death Dis, 2022 Jul 22. PMID 35869062, Free PMC Article

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SENP3-regulated Nodal signaling plays a potential role in cardiac left-right asymmetry development.
      Title: SENP3-regulated Nodal signaling plays a potential role in cardiac left-right asymmetry development.
    2. SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1.
      Title: SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1.
    3. Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation.
      Title: Myeloid SENP3 deficiency protects mice from diet and age-induced obesity via regulation of YAP1 SUMOylation.
    4. SENP3 facilitates M1 macrophage polarization via the HIF-1alpha/PKM2 axis in lipopolysaccharide-induced acute lung injury.
      Title: SENP3 facilitates M1 macrophage polarization via the HIF-1α/PKM2 axis in lipopolysaccharide-induced acute lung injury.
    5. Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage.
      Title: Loss of SENP3 mediated the formation of nasal polyps in nasal mucosal inflammation by increasing alternative activated macrophage.
    6. Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity.
      Title: Mitotic SENP3 activation couples with cGAS signaling in tumor cells to stimulate anti-tumor immunity.
    7. SENP3 loss promotes M2 macrophage polarization and breast cancer progression.
      Title: SENP3 loss promotes M2 macrophage polarization and breast cancer progression.
    8. Redox-sensitive enzyme SENP3 mediates vascular remodeling via de-SUMOylation of beta-catenin and regulation of its stability.
      Title: Redox-sensitive enzyme SENP3 mediates vascular remodeling via de-SUMOylation of β-catenin and regulation of its stability.
    9. SENP3 in monocytes/macrophages up-regulates tissue factor and mediates lipopolysaccharide-induced acute lung injury by enhancing JNK phosphorylation.
      Title: SENP3 in monocytes/macrophages up-regulates tissue factor and mediates lipopolysaccharide-induced acute lung injury by enhancing JNK phosphorylation.
    10. A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3.
      Title: A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deSUMOylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deSUMOylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deSUMOylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of double-strand break repair via homologous recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein desumoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein desumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within protein metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MLL1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    sentrin-specific protease 3
    Names
    SUMO-1-specific protease 3
    SUMO/sentrin specific protease 3
    sentrin/SUMO-specific protease SENP3
    smt3-specific isopeptidase 1
    NP_001157043.1
    NP_109627.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163571.1 → NP_001157043.1  sentrin-specific protease 3

      See identical proteins and their annotated locations for NP_001157043.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AL603707
      Consensus CDS
      CCDS24905.1
      UniProtKB/Swiss-Prot
      Q5F2A5, Q8BRD5, Q8C2H5, Q9EP97
      Related
      ENSMUSP00000066581.2, ENSMUST00000066760.8
      Conserved Domains (1) summary
      pfam02902
      Location:394 → 566
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    2. NM_030702.4 → NP_109627.3  sentrin-specific protease 3

      See identical proteins and their annotated locations for NP_109627.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK045071, AY008764, BY134888
      Consensus CDS
      CCDS24905.1
      UniProtKB/Swiss-Prot
      Q5F2A5, Q8BRD5, Q8C2H5, Q9EP97
      Related
      ENSMUSP00000005336.3, ENSMUST00000005336.9
      Conserved Domains (1) summary
      pfam02902
      Location:394 → 566
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69563936..69572910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EP97.1 GenPept UniProtKB/Swiss-Prot:Q9EP97

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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