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    C1qtnf2 C1q and tumor necrosis factor related protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 69183, updated on 9-Dec-2024

    Summary

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    Official Symbol
    C1qtnf2provided by MGI
    Official Full Name
    C1q and tumor necrosis factor related protein 2provided by MGI
    Primary source
    MGI:MGI:1916433
    See related
    Ensembl:ENSMUSG00000046491 AllianceGenome:MGI:1916433
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Adih; CTRP2; 1810033K05Rik
    Summary
    Enables identical protein binding activity and signaling receptor binding activity. Involved in regulation of lipid metabolic process. Acts upstream of or within positive regulation of D-glucose import; positive regulation of MAPK cascade; and positive regulation of small molecule metabolic process. Located in extracellular space. Part of protein-containing complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and skeleton. Orthologous to human C1QTNF2 (C1q and TNF related 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 20.0), bladder adult (RPKM 18.2) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See C1qtnf2 in Genome Data Viewer
    Location:
    11 25.72 cM; 11 B1.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (43364984..43382485)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (43474306..43491525)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6968 Neighboring gene SLU7 splicing factor homolog (S. cerevisiae) Neighboring gene predicted gene 12151 Neighboring gene STARR-seq mESC enhancer starr_29256 Neighboring gene cyclin J-like Neighboring gene STARR-seq mESC enhancer starr_29259 Neighboring gene STARR-seq mESC enhancer starr_29260 Neighboring gene fatty acid binding protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. C1q/TNF-related protein-2 improved angiogenesis to protect myocardial function during ischaemia‒reperfusion. Ye M, et al. Diab Vasc Dis Res, 2022 Nov-Dec. PMID 36409464, Free PMC Article
    2. CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice. Peterson JM, et al. PLoS One, 2014. PMID 24586339, Free PMC Article
    3. C1q/TNF-related protein 2 (CTRP2) deletion promotes adipose tissue lipolysis and hepatic triglyceride secretion. Lei X, et al. J Biol Chem, 2019 Oct 25. PMID 31439668, Free PMC Article
    4. Expression of adipokines in preimplantation rabbit and mice embryos. Schmidt T, et al. Histochem Cell Biol, 2008 Jun. PMID 18330590
    5. A family of Acrp30/adiponectin structural and functional paralogs. Wong GW, et al. Proc Natl Acad Sci U S A, 2004 Jul 13. PMID 15231994, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. C1q/TNF-related protein-2 improved angiogenesis to protect myocardial function during ischaemiareperfusion.
      Title: C1q/TNF-related protein-2 improved angiogenesis to protect myocardial function during ischaemia‒reperfusion.
    2. CTRP2 regulates lipid metabolism in adipose tissue and liver.
      Title: C1q/TNF-related protein 2 (CTRP2) deletion promotes adipose tissue lipolysis and hepatic triglyceride secretion.
    3. CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice.
      Title: CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of D-glucose import IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of fatty acid oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of glycogen biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of lipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    complement C1q tumor necrosis factor-related protein 2
    Names
    adiponectin h

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026979.6 → NP_081255.2  complement C1q tumor necrosis factor-related protein 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AL670472
      Consensus CDS
      CCDS24558.1
      UniProtKB/TrEMBL
      A0A3B0IYV7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      43364984..43382485
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156958.1 → XP_036012851.1  complement C1q tumor necrosis factor-related protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9D8U4
      UniProtKB/TrEMBL
      A0A3B0IYV7
      Related
      ENSMUSP00000051652.4, ENSMUST00000057679.10
      Conserved Domains (2) summary
      pfam00386
      Location:160 → 284
      C1q; C1q domain
      pfam01391
      Location:79 → 130
      Collagen; Collagen triple helix repeat (20 copies)

    2. XM_036156959.1 → XP_036012852.1  complement C1q tumor necrosis factor-related protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q9D8U4
      UniProtKB/TrEMBL
      A0A3B0IYV7
      Conserved Domains (2) summary
      pfam00386
      Location:160 → 284
      C1q; C1q domain
      pfam01391
      Location:79 → 130
      Collagen; Collagen triple helix repeat (20 copies)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8U4.1 GenPept UniProtKB/Swiss-Prot:Q9D8U4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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