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    Map7d2 MAP7 domain containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 78283, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Map7d2provided by MGI
    Official Full Name
    MAP7 domain containing 2provided by MGI
    Primary source
    MGI:MGI:1917474
    See related
    Ensembl:ENSMUSG00000041020 AllianceGenome:MGI:1917474
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mtap7d2; 1600028E09Rik; 2900002G04Rik; 5330432J06Rik; C030036K04Rik
    Summary
    Predicted to be involved in microtubule cytoskeleton organization. Predicted to be active in microtubule cytoskeleton. Is expressed in nervous system. Orthologous to human MAP7D2 (MAP7 domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 18.4), frontal lobe adult (RPKM 11.9) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Map7d2 in Genome Data Viewer
    Location:
    X F4; X 73.45 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (158197488..158281954)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (159414492..159498958)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 1A, X-linked Neighboring gene predicted gene 15187 Neighboring gene STARR-seq mESC enhancer starr_48172 Neighboring gene STARR-seq mESC enhancer starr_48173 Neighboring gene predicted gene, 39546 Neighboring gene STARR-seq mESC enhancer starr_48174 Neighboring gene STARR-positive B cell enhancer mm9_chrX:155970286-155970586 Neighboring gene Bclaf1 and Thrap3 family member 3 Neighboring gene hepatitis B virus x interacting protein pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Phenotypic annotation of the mouse X chromosome. Cox BJ, et al. Genome Res, 2010 Aug. PMID 20548051, Free PMC Article
    2. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
    3. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    4. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    5. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    MAP7 domain-containing protein 2
    Names
    novel E-MAP-115 family protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081124.2 → NP_001074593.1  MAP7 domain-containing protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001074593.1

      Status: VALIDATED

      Source sequence(s)
      AK013466, AK030316, AL672284, BE952779, CK620800
      Consensus CDS
      CCDS41193.1
      UniProtKB/Swiss-Prot
      A2AG50, A2AG54, Q8BLE6, Q8BMQ4, Q9D2A4
      Related
      ENSMUSP00000108090.3, ENSMUST00000112471.9
      Conserved Domains (2) summary
      pfam05672
      Location:433 → 608
      MAP7; MAP7 (E-MAP-115) family
      pfam11208
      Location:76 → 141
      DUF2992; Protein of unknown function (DUF2992)

    2. NM_001313751.1 → NP_001300680.1  MAP7 domain-containing protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK030316, AK162227, BE952779, CK620800
      UniProtKB/Swiss-Prot
      A2AG50
      UniProtKB/TrEMBL
      Q3TS73
      Conserved Domains (2) summary
      pfam05672
      Location:400 → 575
      MAP7; MAP7 (E-MAP-115) family
      pfam11208
      Location:76 → 141
      DUF2992; Protein of unknown function (DUF2992)

    3. NM_001313752.1 → NP_001300681.1  MAP7 domain-containing protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AK019929
      Consensus CDS
      CCDS85823.1
      UniProtKB/Swiss-Prot
      A2AG50
      Related
      ENSMUSP00000108089.2, ENSMUST00000112470.3
      Conserved Domains (1) summary
      pfam05672
      Location:249 → 276
      MAP7; MAP7 (E-MAP-115) family

    4. NM_001313753.1 → NP_001300682.1  MAP7 domain-containing protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AK019929, AK030316, BE952779
      Consensus CDS
      CCDS85824.1
      UniProtKB/Swiss-Prot
      A2AG50
      Related
      ENSMUSP00000046693.6, ENSMUST00000043151.12
      Conserved Domains (1) summary
      pfam05672
      Location:247 → 424
      MAP7; MAP7 (E-MAP-115) family

    5. NM_001359310.1 → NP_001346239.1  MAP7 domain-containing protein 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL672284, BE952779
      Conserved Domains (2) summary
      pfam05672
      Location:433 → 589
      MAP7; MAP7 (E-MAP-115) family
      cl25549
      Location:75 → 168
      ARGLU; Arginine and glutamate-rich 1

    6. NM_001359311.1 → NP_001346240.1  MAP7 domain-containing protein 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL672284, BE952779
      Conserved Domains (2) summary
      pfam05672
      Location:396 → 571
      MAP7; MAP7 (E-MAP-115) family
      cl25742
      Location:75 → 164
      ERM; Ezrin/radixin/moesin family

    7. NM_001359313.1 → NP_001346242.1  MAP7 domain-containing protein 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL672284, BE952779
      Conserved Domains (2) summary
      pfam05672
      Location:400 → 556
      MAP7; MAP7 (E-MAP-115) family
      cl25742
      Location:75 → 164
      ERM; Ezrin/radixin/moesin family

    8. NM_001359314.1 → NP_001346243.1  MAP7 domain-containing protein 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL672284, BE952779
      Conserved Domains (2) summary
      pfam05672
      Location:396 → 552
      MAP7; MAP7 (E-MAP-115) family
      cl25549
      Location:75 → 168
      ARGLU; Arginine and glutamate-rich 1

    9. NM_001359315.1 → NP_001346244.1  MAP7 domain-containing protein 2 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL672284, BE952779
      Conserved Domains (2) summary
      pfam05672
      Location:363 → 538
      MAP7; MAP7 (E-MAP-115) family
      pfam05914
      Location:70 → 141
      RIB43A; RIB43A

    10. NM_001359317.1 → NP_001346246.1  MAP7 domain-containing protein 2 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL672284, BE952779
      Conserved Domains (2) summary
      pfam05672
      Location:363 → 519
      MAP7; MAP7 (E-MAP-115) family
      pfam05914
      Location:70 → 141
      RIB43A; RIB43A

    11. NM_001359320.1 → NP_001346249.1  MAP7 domain-containing protein 2 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL672284, BE952779
      Conserved Domains (1) summary
      pfam05672
      Location:280 → 457
      MAP7; MAP7 (E-MAP-115) family

    12. NM_001359321.1 → NP_001346250.1  MAP7 domain-containing protein 2 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AL672284, BE952779
      Conserved Domains (1) summary
      pfam05672
      Location:282 → 438
      MAP7; MAP7 (E-MAP-115) family

    13. NM_001359322.1 → NP_001346251.1  MAP7 domain-containing protein 2 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AL672284, BE952779
      Conserved Domains (1) summary
      pfam05672
      Location:212 → 382
      MAP7; MAP7 (E-MAP-115) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      158197488..158281954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318641.2 → XP_017174130.1  MAP7 domain-containing protein 2 isoform X2

      Conserved Domains (2) summary
      pfam05672
      Location:361 → 533
      MAP7; MAP7 (E-MAP-115) family
      pfam17380
      Location:75 → 168
      DUF5401; Family of unknown function (DUF5401)

    2. XM_011247881.4 → XP_011246183.1  MAP7 domain-containing protein 2 isoform X1

      Conserved Domains (2) summary
      pfam05672
      Location:431 → 603
      MAP7; MAP7 (E-MAP-115) family
      pfam17380
      Location:75 → 168
      DUF5401; Family of unknown function (DUF5401)

    3. XM_036162119.1 → XP_036018012.1  MAP7 domain-containing protein 2 isoform X4

      Conserved Domains (1) summary
      pfam05672
      Location:247 → 419
      MAP7; MAP7 (E-MAP-115) family

    4. XM_030251520.1 → XP_030107380.1  MAP7 domain-containing protein 2 isoform X5

      Conserved Domains (1) summary
      pfam05672
      Location:280 → 457
      MAP7; MAP7 (E-MAP-115) family

    5. XM_030251519.2 → XP_030107379.1  MAP7 domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      pfam05672
      Location:247 → 424
      MAP7; MAP7 (E-MAP-115) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AG50.1 GenPept UniProtKB/Swiss-Prot:A2AG50

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