Insl5 insulin-like 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Insl5provided by MGI
Official Full Name: insulin-like 5provided by MGI
Primary source: MGI:MGI:1346085
See related: Ensembl:ENSMUSG00000066090 AllianceGenome:MGI:1346085
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RIF2
Summary: Predicted to enable G protein-coupled receptor binding activity. Acts upstream of or within positive regulation of feeding behavior. Located in collagen-containing extracellular matrix. Is expressed in several structures, including adipose tissue; brain; gut; hemolymphoid system gland; and retina. Orthologous to human INSL5 (insulin like 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in colon adult (RPKM 40.9) and thymus adult (RPKM 3.7) See more
Orthologs: human all
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Genomic context

Location:: 4 C6; 4 47.27 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (102875069..102884468, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (103017872..103027271, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immune System Effects of Insulin-Like Peptide 5 in a Mouse Model.
Title: Immune System Effects of Insulin-Like Peptide 5 in a Mouse Model.
Mass spectral analysis of purified enteroendocrine cells and tissue homogenates identified the exact sequence of A and B chains of INSL5 endogenously expressed in L-cells.
Title: Liquid chromatography/mass spectrometry based detection and semi-quantitative analysis of INSL5 in human and murine tissues.
Insl5 is an orexigenic hormone released from colonic L-cells, which promotes appetite during conditions of energy deprivation.
Title: Insulin-like peptide 5 is an orexigenic gastrointestinal hormone.
INSL5 may be a unique marker of colorectal enteroendocrine cells, and INSL5-RXFP4 signaling might play a role in an autocrine/paracrine fashion in the colorectal epithelium and rectal neuroendocrine tumors.
Title: INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors.
Insl5 knockout mice displayed impaired male and female fertility that are due to marked reduction in sperm motility and irregular length of the estrous cycle. Also impaired glucose homeostasis due to glucose intolerance.
Title: INSL5-deficient mice display an alteration in glucose homeostasis and an impaired fertility.
Insulin-like peptide 5 is expressed in mouse brain and has a role in mobilization of calcium
Title: Insulin-like peptide 5: expression in the mouse brain and mobilization of calcium.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

General gene information

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Markers

Insl5 (e-PCR), detects polymorphism
- UniSTS:495956

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of feeding behavior	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of feeding behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: insulin-like peptide INSL5

Names: relaxin/insulin-like factor 2; relaxin/insulin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290648.2 → NP_001277577.1 insulin-like peptide INSL5 isoform 1 precursor

See identical proteins and their annotated locations for NP_001277577.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL732543, BX004765

Consensus CDS

CCDS71431.1

UniProtKB/TrEMBL

A2AIY3

Related

ENSMUSP00000102482.3, ENSMUST00000106869.3

Conserved Domains (1) summary

cd04365
Location:35 → 145

IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...
NM_011831.3 → NP_035961.1 insulin-like peptide INSL5 isoform 2 precursor

See identical proteins and their annotated locations for NP_035961.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AL732543, BX004765

Consensus CDS

CCDS18406.1

UniProtKB/Swiss-Prot

Q9WUG6

Related

ENSMUSP00000081416.6, ENSMUST00000084382.6

Conserved Domains (1) summary

cd04365
Location:25 → 135

IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...