Smoc2 SPARC related modular calcium binding 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Smoc2provided by MGI
Official Full Name: SPARC related modular calcium binding 2provided by MGI
Primary source: MGI:MGI:1929881
See related: Ensembl:ENSMUSG00000023886 AllianceGenome:MGI:1929881
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Smoc2l; 1700056C05Rik; 5430426J21Rik
Summary: Enables calcium ion binding activity and heparin binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane and interstitial matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and hemolymphoid system gland. Orthologous to human SMOC2 (SPARC related modular calcium binding 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in ovary adult (RPKM 125.2), subcutaneous fat pad adult (RPKM 55.4) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A2; 17 8.95 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (14499768..14625052)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (14279490..14404790)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

microRNA-148a in Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviates Cardiomyocyte Apoptosis in Atrial Fibrillation by Inhibiting SMOC2.
Title: microRNA-148a in Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviates Cardiomyocyte Apoptosis in Atrial Fibrillation by Inhibiting SMOC2.
Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2.
Title: Smoc1 and Smoc2 regulate bone formation as downstream molecules of Runx2.
A SMOC2 variant inhibits BMP signaling by competitively binding to BMPR1B and causes growth plate defects.
Title: A SMOC2 variant inhibits BMP signaling by competitively binding to BMPR1B and causes growth plate defects.
Liver fibrosis induced by high fat diet was clearly ameliorated by SMOC2 deficiency mainly through inhibiting transforming growth factor (TGF)-beta1 expression.
Title: Secreted modular calcium-binding protein 2 promotes high fat diet (HFD)-induced hepatic steatosis through enhancing lipid deposition, fibrosis and inflammation via targeting TGF-β1.
SMOC2 can act as an inhibitor of mineralization; there is a possible role for SMOC2 to prevent calcification disorders.
Title: SMOC2 inhibits calcification of osteoprogenitor and endothelial cells.
By using microRNA array, we identified a large number of microRNAs that showed different expression between wild-type Runx2 group and mutant groups. The aim of this study is to find out the effect of mmu-miR-1963, which was downregulated in all mutant Runx2 groups, on the ameloblast differentiation of LS8 cells
Title: mmu-miR-1963 negatively regulates the ameloblast differentiation of LS8 cell line by directly targeting Smoc2 3'UTR.
SMOC1 and SMOC2 may mediate intercellular signaling and cell type-specific differentiation during gonad and reproductive tract development
Title: Developmental expression of Smoc1 and Smoc2 suggests potential roles in fetal gonad and reproductive tract differentiation.
results indicate that Smoc2 is a novel transcriptional target of activated Ahr. Perturbation of Smoc2 expression may mediate the adverse developmental effects of environmental aryl-hydrocarbon exposure
Title: The developmentally-regulated Smoc2 gene is repressed by Aryl-hydrocarbon receptor (Ahr) signaling.
SMOC-2 contributes to cell cycle progression by maintaining ILK activity during G1.
Title: The SPARC-related factor SMOC-2 promotes growth factor-induced cyclin D1 expression and DNA synthesis via integrin-linked kinase.
SMOC-2, like other members of the BM40/SPARC family, acts as a regulator of cell-matrix interactions.
Title: The widely expressed extracellular matrix protein SMOC-2 promotes keratinocyte attachment and migration.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237575

Smoc2 (e-PCR), detects polymorphism
- UniSTS:498279

D17Jcs33 (e-PCR), detects polymorphism
- UniSTS:259276

D17Jcs34 (e-PCR), detects polymorphism
- UniSTS:259277

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables extracellular matrix binding	IBA Inferred from Biological aspect of Ancestor more info
enables glycosaminoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in extracellular matrix organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extracellular matrix organization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-substrate adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of endothelial cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular wound healing	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in interstitial matrix	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SPARC-related modular calcium-binding protein 2

Names: SMOC-2; secreted modular calcium-binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022315.2 → NP_071710.2 SPARC-related modular calcium-binding protein 2 precursor

See identical proteins and their annotated locations for NP_071710.2

Status: VALIDATED

Source sequence(s)

AK030958, BB840063, BY690973

Consensus CDS

CCDS37442.1

UniProtKB/Swiss-Prot

Q8CD91, Q8VCM1, Q9D9K2, Q9ER95

UniProtKB/TrEMBL

Q3TVR8

Related

ENSMUSP00000024660.9, ENSMUST00000024660.9

Conserved Domains (4) summary

smart00280
Location:39 → 84

KAZAL; Kazal type serine protease inhibitors

cd00191
Location:215 → 281

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

cd00252
Location:352 → 413

SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...

pfam16597
Location:154 → 212

Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

14499768..14625052

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524777.4 → XP_006524840.1 SPARC-related modular calcium-binding protein 2 isoform X1

UniProtKB/TrEMBL

A0A3B2WCK7, Q3TVR8

Related

ENSMUSP00000156572.2, ENSMUST00000233344.2

Conserved Domains (5) summary

smart00280
Location:39 → 84

KAZAL; Kazal type serine protease inhibitors

cd00191
Location:226 → 292

TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases

cd16241
Location:315 → 428

EFh_SPARC_SMOC2; EF-hand, extracellular calcium-binding (EC) motif, found in secreted modular calcium-binding protein 2 (SMOC-2)

pfam00086
Location:90 → 153

Thyroglobulin_1; Thyroglobulin type-1 repeat

pfam16597
Location:154 → 225

Thyroglob_assoc; Thyroglobulin_1 repeat associated disordered domain