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    Naf1 nuclear assembly factor 1 ribonucleoprotein [ Mus musculus (house mouse) ]

    Gene ID: 234344, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Naf1provided by MGI
    Official Full Name
    nuclear assembly factor 1 ribonucleoproteinprovided by MGI
    Primary source
    MGI:MGI:2682306
    See related
    Ensembl:ENSMUSG00000014907 AllianceGenome:MGI:2682306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm174
    Summary
    Predicted to enable identical protein binding activity and telomerase RNA binding activity. Involved in RNA stabilization. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of sno(s)RNA-containing ribonucleoprotein complex. Human ortholog(s) of this gene implicated in melanoma. Orthologous to human NAF1 (nuclear assembly factor 1 ribonucleoprotein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 9.7), ovary adult (RPKM 7.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Naf1 in Genome Data Viewer
    Location:
    8 B3.1; 8 33.18 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (67312594..67343216)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (66859943..66890564)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene neuropeptide Y receptor Y1 Neighboring gene STARR-seq mESC enhancer starr_21679 Neighboring gene STARR-positive B cell enhancer ABC_E8235 Neighboring gene RNA binding motif protein 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_21680 Neighboring gene STARR-seq mESC enhancer starr_21683 Neighboring gene predicted gene, 39185 Neighboring gene predicted gene, 25275 Neighboring gene STARR-seq mESC enhancer starr_21684 Neighboring gene STARR-seq mESC enhancer starr_21685 Neighboring gene STARR-seq mESC enhancer starr_21686 Neighboring gene STARR-seq mESC enhancer starr_21687 Neighboring gene FGFR1 oncogene partner 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss-of-function mutations in the RNA biogenesis factor NAF1 predispose to pulmonary fibrosis-emphysema. Stanley SE, et al. Sci Transl Med, 2016 Aug 10. PMID 27510903, Free PMC Article
    2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    4. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in box H/ACA snoRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in box H/ACA snoRNP assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of telomere maintenance via telomere lengthening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosome biogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in snoRNA guided rRNA pseudouridine synthesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in telomerase RNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in telomerase holoenzyme complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of sno(s)RNA-containing ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of sno(s)RNA-containing ribonucleoprotein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of sno(s)RNA-containing ribonucleoprotein complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    H/ACA ribonucleoprotein complex non-core subunit NAF1
    Names
    nuclear assembly factor 1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163564.1 → NP_001157036.1  H/ACA ribonucleoprotein complex non-core subunit NAF1

      Status: VALIDATED

      Source sequence(s)
      AC116731, AK144735
      Consensus CDS
      CCDS52562.1
      UniProtKB/TrEMBL
      E9QJT2
      Related
      ENSMUSP00000112640.2, ENSMUST00000118009.2
      Conserved Domains (2) summary
      pfam04410
      Location:281 → 429
      Gar1; Gar1/Naf1 RNA binding region
      pfam05454
      Location:55 → 125
      DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      67312594..67343216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153916.1 → XP_036009809.1  H/ACA ribonucleoprotein complex non-core subunit NAF1 isoform X1

      Conserved Domains (2) summary
      PHA03269
      Location:53 → 130
      PHA03269; envelope glycoprotein C; Provisional
      PRK12323
      Location:10 → 212
      PRK12323; DNA polymerase III subunit gamma/tau

    RNA

    1. XR_003947254.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UMQ8.2 GenPept UniProtKB/Swiss-Prot:Q3UMQ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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