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    Cpb1 carboxypeptidase B1 [ Mus musculus (house mouse) ]

    Gene ID: 76703, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cpb1provided by MGI
    Official Full Name
    carboxypeptidase B1provided by MGI
    Primary source
    MGI:MGI:1923953
    See related
    Ensembl:ENSMUSG00000011463 AllianceGenome:MGI:1923953
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0910001A18Rik; 1810063F02Rik; 2210008M23Rik
    Summary
    Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in extracellular space. Is expressed in alimentary system; brain; genitourinary system; thymus; and trachea. Orthologous to human CPB1 (carboxypeptidase B1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in small intestine adult (RPKM 332.2), spleen adult (RPKM 215.9) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cpb1 in Genome Data Viewer
    Location:
    3 A2; 3 6.29 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (20303643..20339681, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (20249479..20275733, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31320 Neighboring gene microRNA 7007 Neighboring gene carboxypeptidase A3, mast cell Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_07114 Neighboring gene angiotensin II receptor, type 1b Neighboring gene crumbs homolog 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis. Chatterjee S, et al. J Immunol, 2009 Sep 15. PMID 19717511, Free PMC Article
    2. The gene mutated in cocoa mice, carrying a defect of organelle biogenesis, is a homologue of the human Hermansky-Pudlak syndrome-3 gene. Suzuki T, et al. Genomics, 2001 Nov. PMID 11707070
    3. von Hippel-Lindau gene disruption in mouse pancreatic progenitors and its consequences on endocrine differentiation in vivo: importance of HIF1-α and VEGF-A upregulation. Soggia A, et al. Diabetologia, 2014 Nov. PMID 25186293
    4. The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis. Hale MA, et al. Development, 2014 Aug. PMID 25063451, Free PMC Article
    5. A molecular profile of a hematopoietic stem cell niche. Hackney JA, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12226475, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CPB1 colocalization, coupling, and proximity to NOS-3 in the sinus-lining cells of spleen red pulp could explain the site-specific tyrosine nitration and inactivation of CPB1
      Title: Site-specific carboxypeptidase B1 tyrosine nitration and pathophysiological implications following its physical association with nitric oxide synthase-3 in experimental sepsis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase B
    Names
    carboxypeptidase B1 (tissue)
    NP_083982.1
    XP_036019285.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029706.2 → NP_083982.1  carboxypeptidase B precursor

      See identical proteins and their annotated locations for NP_083982.1

      Status: VALIDATED

      Source sequence(s)
      AC158937, AK003061, AK008678, BQ831426
      Consensus CDS
      CCDS17263.1
      UniProtKB/TrEMBL
      B2RS76
      Related
      ENSMUSP00000011607.6, ENSMUST00000011607.6
      Conserved Domains (2) summary
      cd03871
      Location:112 → 411
      M14_CPB; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B subgroup
      pfam02244
      Location:31 → 102
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      20303643..20339681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163392.1 → XP_036019285.1  carboxypeptidase B isoform X1

      UniProtKB/TrEMBL
      B2RS76
      Conserved Domains (2) summary
      cd03871
      Location:112 → 411
      M14_CPB; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B subgroup
      pfam02244
      Location:31 → 102
      Propep_M14; Carboxypeptidase activation peptide
    Nucleotide Protein Strain
    Heading Accession and Version

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