Add3 adducin 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Add3provided by MGI
Official Full Name: adducin 3provided by MGI
Primary source: MGI:MGI:1351615
See related: Ensembl:ENSMUSG00000025026 AllianceGenome:MGI:1351615
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: A structural constituent of cytoskeleton. Predicted to be involved in positive regulation of vasoconstriction; regulation of cytoskeleton organization; and response to xenobiotic stimulus. Located in several cellular components, including brush border; condensed nuclear chromosome; and postsynaptic density. Is expressed in central nervous system; chondrocranium; gut; tail unsegmented mesenchyme; and vertebral axis musculature. Human ortholog(s) of this gene implicated in spastic quadriplegic cerebral palsy 3. Orthologous to human ADD3 (adducin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 34.1), cerebellum adult (RPKM 18.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 D2; 19 47.18 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (53128874..53235518)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (53140443..53247326)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C-terminal 38 amino acids of gamma-adducin interact with F-actins around the Golgi complex, to facilitate exit of POMC/ACTH vesicles.
Title: γ-Adducin promotes process outgrowth and secretory protein exit from the Golgi apparatus.
These results strongly suggest coordinated expression and phosphorylation of alpha-, beta-, and gamma-adducins as key mechanism underlying synaptic plasticity, motor coordination performance and learning behaviors.
Title: beta-adducin (Add2) KO mice show synaptic plasticity, motor coordination and behavioral deficits accompanied by changes in the expression and phosphorylation levels of the alpha- and gamma-adducin subunits.
Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
Title: Targeted deletion of alpha-adducin results in absent beta- and gamma-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI463285 (e-PCR)
- UniSTS:160859

Add3 (e-PCR), detects polymorphism
- UniSTS:158677

RH125221 (e-PCR)
- UniSTS:162043

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	IEA Inferred from Electronic Annotation more info
enables protein kinase C binding	ISO Inferred from Sequence Orthology more info
enables structural constituent of cytoskeleton	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in condensed nuclear chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: gamma-adducin

Names: adducin 3 (gamma); adducin-like protein 70; cytoskeletal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164099.3 → NP_001157571.1 gamma-adducin isoform a

See identical proteins and their annotated locations for NP_001157571.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, and 5 encode the same isoform (a).

Source sequence(s)

AC138174

Consensus CDS

CCDS29900.1

UniProtKB/Swiss-Prot

Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6

UniProtKB/TrEMBL

Q05C56

Related

ENSMUSP00000158149.2, ENSMUST00000237301.2

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001164100.3 → NP_001157572.1 gamma-adducin isoform b

See identical proteins and their annotated locations for NP_001157572.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 3 and 4 encode the same isoform (b).

Source sequence(s)

AC138174

Consensus CDS

CCDS50467.1

UniProtKB/TrEMBL

Q3UNK1, Q8BJH2

Related

ENSMUSP00000052245.8, ENSMUST00000050096.15

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001164101.3 → NP_001157573.1 gamma-adducin isoform b

See identical proteins and their annotated locations for NP_001157573.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 3 and 4 encode the same isoform (b).

Source sequence(s)

AC138174

Consensus CDS

CCDS50467.1

UniProtKB/TrEMBL

Q3UNK1, Q8BJH2

Related

ENSMUSP00000107370.4, ENSMUST00000111741.10

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001277100.2 → NP_001264029.1 gamma-adducin isoform a

See identical proteins and their annotated locations for NP_001264029.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 5 encode the same isoform (a).

Source sequence(s)

AC138174

Consensus CDS

CCDS29900.1

UniProtKB/Swiss-Prot

Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6

UniProtKB/TrEMBL

Q05C56

Related

ENSMUSP00000157955.2, ENSMUST00000237430.2

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
NM_001413986.1 → NP_001400915.1 gamma-adducin isoform a

Status: VALIDATED

Source sequence(s)

AC138174

UniProtKB/Swiss-Prot

Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6

UniProtKB/TrEMBL

Q05C56
NM_001413987.1 → NP_001400916.1 gamma-adducin isoform b

Status: VALIDATED

Source sequence(s)

AC138174

UniProtKB/TrEMBL

Q3UNK1, Q8BJH2

Related

ENSMUSP00000158154.2, ENSMUST00000238130.2
NM_013758.5 → NP_038786.2 gamma-adducin isoform a

See identical proteins and their annotated locations for NP_038786.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 5 encode the same isoform (a).

Source sequence(s)

AC138174, AK028481

Consensus CDS

CCDS29900.1

UniProtKB/Swiss-Prot

Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6

UniProtKB/TrEMBL

Q05C56

Related

ENSMUSP00000025999.7, ENSMUST00000025999.7

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

53128874..53235518

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030250961.2 → XP_030106821.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6

UniProtKB/TrEMBL

Q05C56

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_030250965.2 → XP_030106825.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6

UniProtKB/TrEMBL

Q05C56

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_030250963.2 → XP_030106823.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6

UniProtKB/TrEMBL

Q05C56

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_030250960.2 → XP_030106820.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6

UniProtKB/TrEMBL

Q05C56

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...
XM_030250959.2 → XP_030106819.1 gamma-adducin isoform X1

UniProtKB/Swiss-Prot

Q8JZT6, Q9D2M5, Q9QYB5, Q9QYB6

UniProtKB/TrEMBL

Q05C56

Conserved Domains (1) summary

cl00214
Location:137 → 385

Aldolase_II; Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II). ...