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    Rinl Ras and Rab interactor-like [ Mus musculus (house mouse) ]

    Gene ID: 320435, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rinlprovided by MGI
    Official Full Name
    Ras and Rab interactor-likeprovided by MGI
    Primary source
    MGI:MGI:2444024
    See related
    Ensembl:ENSMUSG00000051735 AllianceGenome:MGI:2444024
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5830482F20Rik; 9930116N10Rik
    Summary
    Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within endocytosis. Located in actin cytoskeleton and ruffle. Orthologous to human RINL (Ras and Rab interactor like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in thymus adult (RPKM 20.1), spleen adult (RPKM 12.7) and 11 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rinl in Genome Data Viewer
    Location:
    7 B1; 7 16.93 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28488186..28498390)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28788874..28798965)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene coiled-coil glutamate-rich protein 2 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta Neighboring gene STARR-positive B cell enhancer ABC_E128 Neighboring gene sirtuin 2 Neighboring gene predicted gene, 19897 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565175-29565376 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29565964-29566190 Neighboring gene STARR-positive B cell enhancer ABC_E6528 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29577451-29577634 Neighboring gene nuclear encoded tRNA lysine 24 (anticodon TTT) Neighboring gene STARR-seq mESC enhancer starr_18438 Neighboring gene STARR-positive B cell enhancer ABC_E156 Neighboring gene STARR-positive B cell enhancer ABC_E8158 Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene STARR-seq mESC enhancer starr_18440 Neighboring gene enoyl coenzyme A hydratase 1, peroxisomal

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The guanine nucleotide exchange factor Rin-like controls Tfh cell differentiation via CD28 signaling. Sandner L, et al. J Exp Med, 2023 Nov 6. PMID 37703004, Free PMC Article
    2. Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22. Woller B, et al. Biochim Biophys Acta, 2011 Jun. PMID 21419809, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Clone Names

    • MGC51433

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endocytic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ras and Rab interactor-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358916.1 → NP_001345845.1  ras and Rab interactor-like protein

      Status: VALIDATED

      Source sequence(s)
      AC171210
      Consensus CDS
      CCDS21056.1
      UniProtKB/Swiss-Prot
      Q3TRU0, Q80UW3, Q811H9, Q8BUR6, Q8C0J1
      Related
      ENSMUSP00000146576.2, ENSMUST00000209035.2
      Conserved Domains (2) summary
      pfam02204
      Location:412 → 514
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:43 → 136
      SH2; Src homology 2 (SH2) domain

    2. NM_177158.5 → NP_796132.2  ras and Rab interactor-like protein

      See identical proteins and their annotated locations for NP_796132.2

      Status: VALIDATED

      Source sequence(s)
      AC171210, AK030993, AK162469, BF147913
      Consensus CDS
      CCDS21056.1
      UniProtKB/Swiss-Prot
      Q3TRU0, Q80UW3, Q811H9, Q8BUR6, Q8C0J1
      Related
      ENSMUSP00000058447.8, ENSMUST00000059857.8
      Conserved Domains (2) summary
      pfam02204
      Location:412 → 514
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:43 → 136
      SH2; Src homology 2 (SH2) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28488186..28498390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540098.5 → XP_006540161.3  ras and Rab interactor-like protein isoform X1

      Conserved Domains (2) summary
      pfam02204
      Location:416 → 518
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:96 → 189
      SH2; Src homology 2 (SH2) domain

    2. XM_006540099.1 → XP_006540162.1  ras and Rab interactor-like protein isoform X2

      See identical proteins and their annotated locations for XP_006540162.1

      UniProtKB/Swiss-Prot
      Q3TRU0, Q80UW3, Q811H9, Q8BUR6, Q8C0J1
      Conserved Domains (2) summary
      pfam02204
      Location:412 → 514
      VPS9; Vacuolar sorting protein 9 (VPS9) domain
      cl15255
      Location:43 → 136
      SH2; Src homology 2 (SH2) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80UW3.1 GenPept UniProtKB/Swiss-Prot:Q80UW3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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