Rcc2 regulator of chromosome condensation 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rcc2provided by MGI
Official Full Name: regulator of chromosome condensation 2provided by MGI
Primary source: MGI:MGI:1919784
See related: Ensembl:ENSMUSG00000040945 AllianceGenome:MGI:1919784
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Td60; mKIAA1470; 2610510H01Rik; 2610529N02Rik
Summary: Enables small GTPase binding activity. Involved in several processes, including activation of GTPase activity; negative regulation of GTPase activity; and negative regulation of cell-substrate adhesion. Located in early endosome membrane; nucleus; and plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Orthologous to human RCC2 (regulator of chromosome condensation 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 76.6), CNS E11.5 (RPKM 66.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 72.15 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (140427308..140450531)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (140701473..140723220)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RCC2 Promotes Esophageal Cancer Growth by Regulating Activity and Expression of the Sox2 Transcription Factor.
Title: RCC2 Promotes Esophageal Cancer Growth by Regulating Activity and Expression of the Sox2 Transcription Factor.
EGFR suppression of mitotic regulators including Rcc2 and Stathmin 1 are a mechanism for catagen induction in mouse skin
Title: The epidermal growth factor receptor decreases Stathmin 1 and triggers catagen entry in the mouse.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235081

RH124285 (e-PCR)
- UniSTS:161107

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome passenger complex localization to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome passenger complex localization to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in chromosome passenger complex localization to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of GTPase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of focal adhesion assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of G2/M transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of attachment of spindle microtubules to kinetochore	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of attachment of spindle microtubules to kinetochore	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of attachment of spindle microtubules to kinetochore	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of ruffle assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of ruffle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome, centromeric core domain	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric core domain	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle midzone	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle midzone	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein RCC2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173867.5 → NP_776292.1 protein RCC2

See identical proteins and their annotated locations for NP_776292.1

Status: VALIDATED

Source sequence(s)

AK076040, AL954710, BC060624, CA751510

Consensus CDS

CCDS18852.1

UniProtKB/Swiss-Prot

A2AWQ3, Q6ZPQ0, Q8BK67

Related

ENSMUSP00000038144.6, ENSMUST00000038893.6

Conserved Domains (1) summary

COG5184
Location:129 → 479

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

140427308..140450531

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036163571.1 → XP_036019464.1 protein RCC2 isoform X1

UniProtKB/Swiss-Prot

A2AWQ3, Q6ZPQ0, Q8BK67

Related

ENSMUSP00000071163.3, ENSMUST00000071169.9

Conserved Domains (1) summary

COG5184
Location:129 → 479

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
XM_006538471.4 → XP_006538534.1 protein RCC2 isoform X1

See identical proteins and their annotated locations for XP_006538534.1

UniProtKB/Swiss-Prot

A2AWQ3, Q6ZPQ0, Q8BK67

Conserved Domains (1) summary

COG5184
Location:129 → 479

ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]