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    Tada2b transcriptional adaptor 2B [ Mus musculus (house mouse) ]

    Gene ID: 231151, updated on 23-Dec-2024

    Summary

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    Official Symbol
    Tada2bprovided by MGI
    Official Full Name
    transcriptional adaptor 2Bprovided by MGI
    Primary source
    MGI:MGI:3035274
    See related
    Ensembl:ENSMUSG00000029196 AllianceGenome:MGI:3035274
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm145
    Summary
    Predicted to enable chromatin binding activity and transcription coactivator activity. Predicted to be involved in chromatin remodeling and regulation of transcription by RNA polymerase II. Part of SAGA complex. Orthologous to human TADA2B (transcriptional adaptor 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 15.9), adrenal adult (RPKM 14.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tada2b in Genome Data Viewer
    Location:
    5 B3; 5 19.14 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (36631014..36641629, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (36473670..36484285, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene sortilin-related VPS10 domain containing receptor 2 Neighboring gene microRNA 7689 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:36701008-36701161 Neighboring gene STARR-positive B cell enhancer mm9_chr5:36715900-36716201 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:36720744-36720945 Neighboring gene RIKEN cDNA 2210406O10 gene Neighboring gene STARR-positive B cell enhancer ABC_E65 Neighboring gene STARR-positive B cell enhancer ABC_E3572 Neighboring gene GrpE-like 1, mitochondrial Neighboring gene TBC1 domain family, member 14 Neighboring gene coiled-coil domain containing 96 Neighboring gene predicted gene, 32528

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Guelman S, et al. Mol Cell Biol, 2009 Mar. PMID 19103755, Free PMC Article
    2. The human SPT20-containing SAGA complex plays a direct role in the regulation of endoplasmic reticulum stress-induced genes. Nagy Z, et al. Mol Cell Biol, 2009 Mar. PMID 19114550, Free PMC Article
    3. Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo. Martinez E, et al. Mol Cell Biol, 2001 Oct. PMID 11564863, Free PMC Article
    4. A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing. Zhao Y, et al. Mol Cell, 2008 Jan 18. PMID 18206972
    5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of SAGA-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA-type complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional adapter 2-beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170454.1 → NP_001163925.1  transcriptional adapter 2-beta

      See identical proteins and their annotated locations for NP_001163925.1

      Status: VALIDATED

      Source sequence(s)
      AC131803, BB653255
      Consensus CDS
      CCDS51478.1
      UniProtKB/TrEMBL
      D3Z4Z0
      Related
      ENSMUSP00000031097.8, ENSMUST00000031097.8
      Conserved Domains (1) summary
      COG5114
      Location:6 → 415
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      36631014..36641629 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030254386.1 → XP_030110246.1  transcriptional adapter 2-beta isoform X1

      UniProtKB/TrEMBL
      D3YW26
      Conserved Domains (1) summary
      COG5114
      Location:11 → 335
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]

    2. XM_036165052.1 → XP_036020945.1  transcriptional adapter 2-beta isoform X2

      UniProtKB/TrEMBL
      D3YW26
      Conserved Domains (1) summary
      COG5114
      Location:1 → 323
      COG5114; Histone acetyltransferase complex SAGA/ADA, subunit ADA2 [Chromatin structure and dynamics]
    Nucleotide Protein Strain
    Heading Accession and Version

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