Fndc3b fibronectin type III domain containing 3B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fndc3bprovided by MGI
Official Full Name: fibronectin type III domain containing 3Bprovided by MGI
Primary source: MGI:MGI:1919257
See related: Ensembl:ENSMUSG00000039286 AllianceGenome:MGI:1919257
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fad104; mKIAA4164; 1600019O04Rik
Summary: Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Located in endoplasmic reticulum. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; nervous system; and respiratory system. Orthologous to human FNDC3B (fibronectin type III domain containing 3B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in placenta adult (RPKM 16.1), limb E14.5 (RPKM 9.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 A3; 3 10.91 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (27470284..27765469, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (27416135..27711307, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease.
Title: FNDC3B protects steatosis and ferroptosis via the AMPK pathway in alcoholic fatty liver disease.
Findings highlight a physiological role for circRNAs in cardiac repair and indicate that modulation of circFndc3b expression may represent a potential strategy to promote cardiac function and remodeling after MI.
Title: Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis.
miR-215-5p is a negative regulator of adipocyte differentiation through post-transcriptional regulation of FNDC3B and CTNNBIP1 during early adipogenesis
Title: MicroRNA-215 impairs adipocyte differentiation and co-represses FNDC3B and CTNNBIP1.
fad104 suppressed anchorage-independent growth of melanoma cells, and the N-terminal region of FAD104 is essential for inhibiting malignant transformation and STAT3 activity
Title: FAD104, a Regulator of Adipogenesis and Osteogenesis, Interacts with the C-Terminal Region of STAT3 and Represses Malignant Transformation of Melanoma Cells.
It contribute not only to adipogenesis but also to other physiological events like pre-implantation in embryonic developments.
Title: [Molecular Mechanisms of Early-stage Adipocyte Differentiation and Multi-functional Roles of Newly Isolated Adipogenic Factors].
down-regulation of Smad1/5/8 phosphorylation by FAD104 is dependent on the N-terminal region of FAD104 and that fad104 functions as a novel negative regulator of BMP/Smad signaling and is required for proper development for calvarial bone.
Title: FAD104, a regulatory factor of adipogenesis, acts as a novel regulator of calvarial bone formation.
Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation
Title: Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation.
fad104 reciprocally regulates differentiation of adipocytes and osteoblast; functions as a positive regulator in adipocyte differentiation and as a negative regulator in osteoblast differentiation.
Title: Fad104, a positive regulator of adipogenesis, negatively regulates osteoblast differentiation.
Fad104 is essential for the survival of newborns just after birth and important for cell proliferation, adhesion, spreading and migration.
Title: Disruption of the novel gene fad104 causes rapid postnatal death and attenuation of cell proliferation, adhesion, spreading and migration.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D3Mit366 (e-PCR), detects polymorphism
- UniSTS:142397

AW550168 (e-PCR)
- UniSTS:178816

RH118258 (e-PCR)
- UniSTS:123796

fl05f06.x1 (e-PCR)
- UniSTS:201902

RH136630 (e-PCR)
- UniSTS:210610

AA801108 (e-PCR)
- UniSTS:261558

D3Ertd452e (e-PCR), detects polymorphism
- UniSTS:167360

11.MMHAP26FRD8.seq (e-PCR)
- UniSTS:123072

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within type II pneumocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibronectin type III domain-containing protein 3B

Names: HCV NS5A-binding protein 37; factor for adipocyte differentiation 104

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356953.1 → NP_001343882.1 fibronectin type III domain-containing protein 3B

Status: VALIDATED

Source sequence(s)

AC116585, AC118696, AC140372, AK147346

Consensus CDS

CCDS17274.1

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

UniProtKB/TrEMBL

A0A0R4J0H8

Related

ENSMUSP00000141620.2, ENSMUST00000195008.6

Conserved Domains (2) summary

cd00063
Location:691 → 765

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:878 → 950

fn3; Fibronectin type III domain
NM_173182.3 → NP_775274.2 fibronectin type III domain-containing protein 3B

See identical proteins and their annotated locations for NP_775274.2

Status: VALIDATED

Source sequence(s)

AC140372, AK220297, AW491305

Consensus CDS

CCDS17274.1

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

UniProtKB/TrEMBL

A0A0R4J0H8

Related

ENSMUSP00000041495.5, ENSMUST00000046157.10

Conserved Domains (2) summary

cd00063
Location:691 → 765

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:878 → 950

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

27470284..27765469 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006535547.5 → XP_006535610.1 fibronectin type III domain-containing protein 3B isoform X4

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

Conserved Domains (2) summary

cd00063
Location:575 → 690

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:803 → 875

fn3; Fibronectin type III domain
XM_006535541.5 → XP_006535604.1 fibronectin type III domain-containing protein 3B isoform X1

See identical proteins and their annotated locations for XP_006535604.1

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

UniProtKB/TrEMBL

A0A0R4J0H8

Conserved Domains (2) summary

cd00063
Location:691 → 765

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:878 → 950

fn3; Fibronectin type III domain
XM_036163344.1 → XP_036019237.1 fibronectin type III domain-containing protein 3B isoform X2

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

Conserved Domains (2) summary

cd00063
Location:673 → 747

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:860 → 932

fn3; Fibronectin type III domain
XM_011249712.4 → XP_011248014.1 fibronectin type III domain-containing protein 3B isoform X1

See identical proteins and their annotated locations for XP_011248014.1

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

UniProtKB/TrEMBL

A0A0R4J0H8

Conserved Domains (2) summary

cd00063
Location:691 → 765

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:878 → 950

fn3; Fibronectin type III domain
XM_036163342.1 → XP_036019235.1 fibronectin type III domain-containing protein 3B isoform X1

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

UniProtKB/TrEMBL

A0A0R4J0H8

Conserved Domains (2) summary

cd00063
Location:691 → 765

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:878 → 950

fn3; Fibronectin type III domain
XM_006535544.5 → XP_006535607.1 fibronectin type III domain-containing protein 3B isoform X1

See identical proteins and their annotated locations for XP_006535607.1

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

UniProtKB/TrEMBL

A0A0R4J0H8

Conserved Domains (2) summary

cd00063
Location:691 → 765

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:878 → 950

fn3; Fibronectin type III domain
XM_036163347.1 → XP_036019240.1 fibronectin type III domain-containing protein 3B isoform X5

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

Conserved Domains (2) summary

cd00063
Location:557 → 672

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:785 → 857

fn3; Fibronectin type III domain
XM_036163345.1 → XP_036019238.1 fibronectin type III domain-containing protein 3B isoform X2

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

Conserved Domains (2) summary

cd00063
Location:673 → 747

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:860 → 932

fn3; Fibronectin type III domain
XM_036163346.1 → XP_036019239.1 fibronectin type III domain-containing protein 3B isoform X4

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

Conserved Domains (2) summary

cd00063
Location:575 → 690

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:803 → 875

fn3; Fibronectin type III domain
XM_030252836.2 → XP_030108696.1 fibronectin type III domain-containing protein 3B isoform X1

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

UniProtKB/TrEMBL

A0A0R4J0H8

Conserved Domains (2) summary

cd00063
Location:691 → 765

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:878 → 950

fn3; Fibronectin type III domain
XM_017319738.3 → XP_017175227.1 fibronectin type III domain-containing protein 3B isoform X1

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

UniProtKB/TrEMBL

A0A0R4J0H8

Conserved Domains (2) summary

cd00063
Location:691 → 765

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:878 → 950

fn3; Fibronectin type III domain
XM_036163341.1 → XP_036019234.1 fibronectin type III domain-containing protein 3B isoform X1

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

UniProtKB/TrEMBL

A0A0R4J0H8

Conserved Domains (2) summary

cd00063
Location:691 → 765

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:878 → 950

fn3; Fibronectin type III domain
XM_011249711.3 → XP_011248013.1 fibronectin type III domain-containing protein 3B isoform X1

See identical proteins and their annotated locations for XP_011248013.1

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

UniProtKB/TrEMBL

A0A0R4J0H8

Conserved Domains (2) summary

cd00063
Location:691 → 765

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:878 → 950

fn3; Fibronectin type III domain
XM_036163343.1 → XP_036019236.1 fibronectin type III domain-containing protein 3B isoform X1

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

UniProtKB/TrEMBL

A0A0R4J0H8

Conserved Domains (2) summary

cd00063
Location:691 → 765

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:878 → 950

fn3; Fibronectin type III domain
XM_006535546.4 → XP_006535609.1 fibronectin type III domain-containing protein 3B isoform X3

UniProtKB/Swiss-Prot

Q3UWZ2, Q570Z2, Q6NWW9, Q80YF7, Q8BLH9, Q8CH86

Conserved Domains (2) summary

cd00063
Location:623 → 697

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:821 → 881

fn3; Fibronectin type III domain