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    Galk1 galactokinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 14635, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Galk1provided by MGI
    Official Full Name
    galactokinase 1provided by MGI
    Primary source
    MGI:MGI:95730
    See related
    Ensembl:ENSMUSG00000020766 AllianceGenome:MGI:95730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gk; Glk; GALK; Glk1
    Summary
    Enables galactokinase activity. Involved in galactose catabolic process via UDP-galactose. Acts upstream of or within galactitol metabolic process and glycolytic process from galactose. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in cataract and galactokinase deficiency. Orthologous to human GALK1 (galactokinase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 109.7), liver E18 (RPKM 50.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Galk1 in Genome Data Viewer
    Location:
    11 E2; 11 80.91 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115899183..115903545, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116008357..116012719, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SAP30 binding protein Neighboring gene STARR-seq mESC enhancer starr_31181 Neighboring gene predicted gene, 39474 Neighboring gene STARR-seq mESC enhancer starr_31187 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene integrin beta 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115873522-115873709 Neighboring gene STARR-positive B cell enhancer ABC_E306 Neighboring gene STARR-seq mESC enhancer starr_31191 Neighboring gene H3.3 histone B Neighboring gene unkempt family zinc finger Neighboring gene predicted gene, 38482

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Transcriptional control of genes that regulate glycolysis and gluconeogenesis in adult liver. Lemaigre FP, et al. Biochem J, 1994 Oct 1. PMID 7945228, Free PMC Article
    2. Provisional assignment of the gene for uridine monophosphatase-2 (Umph-2) to mouse chromosome 11. Wilson DE, et al. Biochem Genet, 1987 Feb. PMID 3034234
    3. Evidence for unequal crossing over within the mouse T/t complex. Silver LM, et al. Proc Natl Acad Sci U S A, 1980 Oct. PMID 6934533, Free PMC Article
    4. A mouse model of galactose-induced cataracts. Ai Y, et al. Hum Mol Genet, 2000 Jul 22. PMID 10915771
    5. The murine atrial myosin light chain-2 gene: a member of an evolutionarily conserved family of contractile proteins. Doevendans PA, et al. Cytogenet Cell Genet, 2000. PMID 11124527

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Egr-1 and galactokinase have roles in a developmentally regulated chain to prepare the neonate for suckling
      Title: Developmental regulation of galactokinase in suckling mouse liver by the Egr-1 transcription factor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables galactokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables galactokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables galactokinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables galactose binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables galactose binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within galactitol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within galactose catabolic process via UDP-galactose IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in galactose catabolic process via UDP-galactose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in galactose metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within galactose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within galactose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in galactose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within glycolytic process from galactose IC
    Inferred by Curator
    more info
    		 PubMed 
    acts_upstream_of_or_within glycolytic process from galactose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    galactokinase
    Names
    galactose kinase
    NP_058601.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016905.2 → NP_058601.2  galactokinase

      See identical proteins and their annotated locations for NP_058601.2

      Status: VALIDATED

      Source sequence(s)
      AK011103, AK045694, BB771442
      Consensus CDS
      CCDS25654.1
      UniProtKB/Swiss-Prot
      Q9JIA6, Q9R0N0
      UniProtKB/TrEMBL
      Q80UL3, Q9CXZ9
      Related
      ENSMUSP00000021114.5, ENSMUST00000021114.5
      Conserved Domains (4) summary
      PRK05101
      Location:12 → 390
      PRK05101; galactokinase; Provisional
      pfam00288
      Location:128 → 193
      GHMP_kinases_N; GHMP kinases N terminal domain
      pfam08544
      Location:291 → 372
      GHMP_kinases_C; GHMP kinases C terminal
      pfam10509
      Location:19 → 67
      GalKase_gal_bdg; Galactokinase galactose-binding signature

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115899183..115903545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R0N0.2 GenPept UniProtKB/Swiss-Prot:Q9R0N0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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