Lalba lactalbumin, alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lalbaprovided by MGI
Official Full Name: lactalbumin, alphaprovided by MGI
Primary source: MGI:MGI:96742
See related: Ensembl:ENSMUSG00000022991 AllianceGenome:MGI:96742
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lyzg
Summary: Enables lactose synthase activity. Involved in lactose biosynthetic process. Part of protein-containing complex. Is expressed in several structures, including central nervous system; cranium; genitourinary system; integumental system; and sensory organ. Orthologous to human LALBA (lactalbumin alpha). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in mammary gland adult (RPKM 2.4) and subcutaneous fat pad adult (RPKM 0.1) See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 54.48 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (98378281..98380827, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (98480400..98482934, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a folding variant of alpha-lactalbumin has a role in lactating mammary gland apoptosis
Title: Apoptotic cell death in the lactating mammary gland is enhanced by a folding variant of alpha-lactalbumin.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Markers

M80909 (e-PCR)
- UniSTS:124985

AW208827 (e-PCR)
- UniSTS:180827

Lalba (e-PCR), detects polymorphism
- UniSTS:143747

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables lactose synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables lysozyme activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in lactose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha-lactalbumin

Names: lactose synthase B protein; lysozyme g

NP_034809.1

EC 2.4.1.22

XP_006520580.1

EC 2.4.1.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.