Fis1 fission, mitochondrial 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fis1provided by MGI
Official Full Name: fission, mitochondrial 1provided by MGI
Primary source: MGI:MGI:1913687
See related: Ensembl:ENSMUSG00000019054 AllianceGenome:MGI:1913687
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ttc11; 2010003O14Rik
Summary: Predicted to enable identical protein binding activity; lipid binding activity; and molecular adaptor activity. Involved in mitochondrial fission. Located in mitochondrion. Is expressed in heart. Orthologous to human FIS1 (fission, mitochondrial 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 78.3), CNS E14 (RPKM 69.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.06 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (136982129..136995088)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (136953275..136966234)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction.
Title: Targeting an allosteric site in dynamin-related protein 1 to inhibit Fis1-mediated mitochondrial dysfunction.
Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance.
Title: Drp1/Fis1-Dependent Pathologic Fission and Associated Damaged Extracellular Mitochondria Contribute to Macrophage Dysfunction in Endotoxin Tolerance.
DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury.
Title: DNA-PKcs interacts with and phosphorylates Fis1 to induce mitochondrial fragmentation in tubular cells during acute kidney injury.
Hepatic Fis1 regulates mitochondrial integrated stress response and improves metabolic homeostasis.
Title: Hepatic Fis1 regulates mitochondrial integrated stress response and improves metabolic homeostasis.
Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation.
Title: Fis1 ablation in the male germline disrupts mitochondrial morphology and mitophagy, and arrests spermatid maturation.
miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1.
Title: miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1.
Treatment with P110 was protective in both in vitro and in vivo models of septic cardiomyopathy, suggesting a key role of Drp1/Fis1 interaction, and a potential target to reduce its morbidity and mortality.
Title: Drp1/Fis1 interaction mediates mitochondrial dysfunction in septic cardiomyopathy.
Fis1 loss induced delayed onset muscle ultrastructure change (DOMUC) in Type I muscle and strong inflammation in response to acute exhaustive exercise (EE).
Title: Fis1 deficiencies differentially affect mitochondrial quality in skeletal muscle.
a role for Drp1/Fis1-mediated excessive mitochondrial fission and dysfunction, is reported.
Title: Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease.
chronically elevated IL-6 can directly induce DRP-1 and FIS-1 expression through gp130 signaling in cultured myotubes and skeletal muscle.
Title: Regulation of Skeletal Muscle DRP-1 and FIS-1 Protein Expression by IL-6 Signaling.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in autophagy of mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to peptide	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial fission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fission	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial fragmentation involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrion organization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ATP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fatty acid transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fatty acid transport	ISO Inferred from Sequence Orthology more info
involved_in peroxisome fission	IBA Inferred from Biological aspect of Ancestor more info
involved_in peroxisome fission	ISO Inferred from Sequence Orthology more info
involved_in peroxisome fission	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitochondrial fission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein targeting to membrane	ISO Inferred from Sequence Orthology more info
involved_in protein targeting to mitochondrion	IEA Inferred from Electronic Annotation more info
involved_in protein targeting to mitochondrion	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in mitochondrial outer membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial outer membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial outer membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in peroxisomal membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal membrane	ISO Inferred from Sequence Orthology more info
located_in peroxisomal membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitochondrial fission 1 protein

Names: FIS1 homolog; TPR repeat protein 11; fission 1 (mitochondrial outer membrane) homolog; tetratricopeptide repeat domain 11; tetratricopeptide repeat protein 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163243.1 → NP_001156715.1 mitochondrial fission 1 protein isoform 2

See identical proteins and their annotated locations for NP_001156715.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AK008078, CA322565, CD774298

Consensus CDS

CCDS51669.1

UniProtKB/TrEMBL

G3X9U9

Related

ENSMUSP00000106723.2, ENSMUST00000111094.8

Conserved Domains (1) summary

cd12212
Location:4 → 116

Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain
NM_001347504.1 → NP_001334433.1 mitochondrial fission 1 protein isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AC147987

Consensus CDS

CCDS84977.1

UniProtKB/TrEMBL

D3YZ32

Related

ENSMUSP00000106726.2, ENSMUST00000111097.8
NM_025562.3 → NP_079838.1 mitochondrial fission 1 protein isoform 1

See identical proteins and their annotated locations for NP_079838.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK008078, AW988976, CD774298

Consensus CDS

CCDS19757.1

UniProtKB/Swiss-Prot

Q9CQ92

Related

ENSMUSP00000019198.7, ENSMUST00000019198.7

Conserved Domains (1) summary

cd12212
Location:9 → 123

Fis1; Mitochondrial Fission Protein Fis1, cytosolic domain