Zfyve19 zinc finger, FYVE domain containing 19 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfyve19provided by MGI
Official Full Name: zinc finger, FYVE domain containing 19provided by MGI
Primary source: MGI:MGI:1919258
See related: Ensembl:ENSMUSG00000068580 AllianceGenome:MGI:1919258
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ANCHR; 1500041L05Rik
Summary: Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in abscission; mitotic cytokinesis checkpoint signaling; and negative regulation of cytokinesis. Predicted to be located in Flemming body and cytoplasm. Predicted to be active in centrosome; cleavage furrow; and midbody. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in progressive familial intrahepatic cholestasis. Orthologous to human ZFYVE19 (zinc finger FYVE-type containing 19). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 16.6), ovary adult (RPKM 13.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 E5; 2 59.97 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (119039088..119047531)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (119208607..119217050)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ZFYVE19 deficiency: a ciliopathy involving failure of cell division, with cell death.
Title: ZFYVE19 deficiency: a ciliopathy involving failure of cell division, with cell death.
Prevention of Portal-Tract Fibrosis in Zfyve19[-/-] Mouse Model with Adeno-Associated Virus Vector Delivering ZFYVE19.
Title: Prevention of Portal-Tract Fibrosis in Zfyve19(-/-) Mouse Model with Adeno-Associated Virus Vector Delivering ZFYVE19.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-3-phosphate binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol-3-phosphate binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in abscission	IBA Inferred from Biological aspect of Ancestor more info
involved_in abscission	ISO Inferred from Sequence Orthology more info
involved_in midbody abscission	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic cytokinesis checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokinesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cleavage furrow	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: abscission/NoCut checkpoint regulator

Names: zinc finger FYVE domain-containing protein 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164827.1 → NP_001158299.1 abscission/NoCut checkpoint regulator isoform 2

See identical proteins and their annotated locations for NP_001158299.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks a coding exon in the 3' region, as compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, as compared to isoform 1.

Source sequence(s)

AL772264, BC099429, CO038937

Consensus CDS

CCDS50672.1

UniProtKB/TrEMBL

Q4KL52

Related

ENSMUSP00000099577.5, ENSMUST00000102519.5

Conserved Domains (1) summary

cd15749
Location:4 → 54

FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins
NM_028054.3 → NP_082330.2 abscission/NoCut checkpoint regulator isoform 1

See identical proteins and their annotated locations for NP_082330.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK005386, AL772264, BC099429, CO038937

Consensus CDS

CCDS16595.1

UniProtKB/Swiss-Prot

A2AV55, Q8VCV7, Q9DAZ9

Related

ENSMUSP00000087636.5, ENSMUST00000090174.11

Conserved Domains (1) summary

cd15749
Location:4 → 54

FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

119039088..119047531

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252098.1 → XP_030107958.1 abscission/NoCut checkpoint regulator isoform X5

Conserved Domains (3) summary

COG4942
Location:73 → 258

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd15749
Location:17 → 52

FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

cd19817
Location:334 → 378

Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
XM_011239781.2 → XP_011238083.1 abscission/NoCut checkpoint regulator isoform X2

Conserved Domains (3) summary

COG4942
Location:75 → 260

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd15749
Location:4 → 54

FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

cd19817
Location:342 → 386

Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
XM_006500207.2 → XP_006500270.1 abscission/NoCut checkpoint regulator isoform X6

See identical proteins and their annotated locations for XP_006500270.1

Conserved Domains (3) summary

PRK11281
Location:105 → 288

PRK11281; mechanosensitive channel MscK

cd15749
Location:2 → 37

FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

cd19817
Location:326 → 370

Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
XM_006500204.2 → XP_006500267.1 abscission/NoCut checkpoint regulator isoform X3

Conserved Domains (3) summary

COG4942
Location:73 → 259

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd15749
Location:17 → 52

FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

cd19817
Location:341 → 385

Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
XM_030252099.2 → XP_030107959.1 abscission/NoCut checkpoint regulator isoform X8

Conserved Domains (2) summary

cd15749
Location:2 → 37

FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

cd19817
Location:319 → 363

Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
XM_006500205.3 → XP_006500268.1 abscission/NoCut checkpoint regulator isoform X4

Conserved Domains (3) summary

COG4942
Location:75 → 261

EnvC; Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning]

cd15749
Location:4 → 54

FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

cd19817
Location:337 → 381

Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
XM_006500203.4 → XP_006500266.1 abscission/NoCut checkpoint regulator isoform X1

Conserved Domains (3) summary

PRK11281
Location:122 → 305

PRK11281; mechanosensitive channel MscK

cd15749
Location:4 → 54

FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

cd19817
Location:343 → 387

Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
XM_036162583.1 → XP_036018476.1 abscission/NoCut checkpoint regulator isoform X6

Conserved Domains (3) summary

PRK11281
Location:105 → 288

PRK11281; mechanosensitive channel MscK

cd15749
Location:2 → 37

FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

cd19817
Location:326 → 370

Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins
XM_036162584.1 → XP_036018477.1 abscission/NoCut checkpoint regulator isoform X7

Conserved Domains (2) summary

cd15749
Location:2 → 37

FYVE_ZFY19; FYVE-related domain found in FYVE domain-containing protein 19 (ZFY19) and similar proteins

cd19817
Location:325 → 369

Bbox1_ANCHR-like; B-box-type 1 zinc finger found in Abscission/NoCut checkpoint regulator (ANCHR) and similar proteins