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    Gpatch8 G patch domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 237943, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gpatch8provided by MGI
    Official Full Name
    G patch domain containing 8provided by MGI
    Primary source
    MGI:MGI:1918667
    See related
    Ensembl:ENSMUSG00000034621 AllianceGenome:MGI:1918667
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbm1; Gpatc8; mKIAA0553; 5430405G24Rik
    Summary
    Predicted to enable metal ion binding activity and nucleic acid binding activity. Predicted to be active in nucleus. Is expressed in brain; cerebellum; and forebrain. Orthologous to human GPATCH8 (G-patch domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 5.8), CNS E14 (RPKM 5.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpatch8 in Genome Data Viewer
    Location:
    11 D- E1; 11 66.31 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (102366737..102447217, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (102475911..102556391, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 171, member A2 Neighboring gene STARR-positive B cell enhancer ABC_E7070 Neighboring gene integrin alpha 2b Neighboring gene cytochrome b-c1 complex subunit 10 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30811 Neighboring gene STARR-positive B cell enhancer ABC_E10716 Neighboring gene midkine pseudogene 1 Neighboring gene predicted gene, 25337 Neighboring gene STARR-seq mESC enhancer starr_30813 Neighboring gene predicted gene 11627 Neighboring gene frizzled class receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies. Benbarche S, et al. Mol Cell, 2024 May 16. PMID 38688280,
    2. Molecular cloning of Fyn-associated molecules in the mouse central nervous system. Kai N, et al. J Neurosci Res, 1997 Jun 1. PMID 9185665
    3. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression. Borgal L, et al. Cell Cycle, 2016. PMID 26919559, Free PMC Article
    4. Tagging genes with cassette-exchange sites. Cobellis G, et al. Nucleic Acids Res, 2005 Mar 1. PMID 15741177, Free PMC Article
    5. Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Feb 28. PMID 12693553

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies.
      Title: GPATCH8 modulates mutant SF3B1 mis-splicing and pathogenicity in hematologic malignancies.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    G patch domain-containing protein 8
    Names
    Fyn-binding molecule 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159492.1 → NP_001152964.1  G patch domain-containing protein 8

      See identical proteins and their annotated locations for NP_001152964.1

      Status: VALIDATED

      Source sequence(s)
      AK142570, BC035255, BE980248, BY136728, CJ057626, CV555545
      Consensus CDS
      CCDS48944.1
      UniProtKB/Swiss-Prot
      A2A6A1, Q80TY1
      Related
      ENSMUSP00000120649.2, ENSMUST00000143842.2
      Conserved Domains (3) summary
      PRK03918
      Location:82 → 207
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam01585
      Location:40 → 82
      G-patch; G-patch domain
      pfam12171
      Location:136 → 163
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      102366737..102447217 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314538.2 → XP_017170027.1  G patch domain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    2. XM_036156674.1 → XP_036012567.1  G patch domain-containing protein 8 isoform X2

    3. XM_006533251.2 → XP_006533314.1  G patch domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006533314.1

      Conserved Domains (2) summary
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    4. XM_036156675.1 → XP_036012568.1  G patch domain-containing protein 8 isoform X2

    5. XM_036156667.1 → XP_036012560.1  G patch domain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    6. XM_030245975.1 → XP_030101835.1  G patch domain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    7. XM_017314541.2 → XP_017170030.1  G patch domain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    8. XM_030245976.1 → XP_030101836.1  G patch domain-containing protein 8 isoform X2

    9. XM_036156665.1 → XP_036012558.1  G patch domain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    10. XM_036156670.1 → XP_036012563.1  G patch domain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    11. XM_036156666.1 → XP_036012559.1  G patch domain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    12. XM_036156668.1 → XP_036012561.1  G patch domain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    13. XM_036156672.1 → XP_036012565.1  G patch domain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    14. XM_006533248.1 → XP_006533311.1  G patch domain-containing protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006533311.1

      Conserved Domains (2) summary
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    15. XM_017314544.2 → XP_017170033.1  G patch domain-containing protein 8 isoform X2

    16. XM_030245977.1 → XP_030101837.1  G patch domain-containing protein 8 isoform X2

    17. XM_036156673.1 → XP_036012566.1  G patch domain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    18. XM_036156669.1 → XP_036012562.1  G patch domain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

    19. XM_036156671.1 → XP_036012564.1  G patch domain-containing protein 8 isoform X1

      Conserved Domains (2) summary
      PRK03918
      Location:4 → 129
      PRK03918; DNA double-strand break repair ATPase Rad50
      pfam12171
      Location:58 → 85
      zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A6A1.1 GenPept UniProtKB/Swiss-Prot:A2A6A1

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