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    MLF3 Mlf3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MLF3
    Official Full Name
    Mlf3p
    Primary source
    SGD:S000005018
    Locus tag
    YNL074C
    See related
    AllianceGenome:SGD:S000005018; FungiDB:YNL074C; VEuPathDB:YNL074C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YMK1
    Summary
    Involved in cellular response to heat and establishment or maintenance of actin cytoskeleton polarity. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MLF3 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (486766..488124, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Mks1p Neighboring gene snoRNA-binding rRNA-processing protein IMP4 Neighboring gene lysine--tRNA ligase MSK1 Neighboring gene ribonuclease H2 catalytic subunit RNH201

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae MLF3/YNL074C gene, encoding a serine-rich protein of unknown function, determines the level of resistance to the novel immunosuppressive drug leflunomide. Fujimura HA. Biochim Biophys Acta, 1998 Nov 8. PMID 9805003
    2. CSS-Palm 2.0: an updated software for palmitoylation sites prediction. Ren J, et al. Protein Eng Des Sel, 2008 Nov. PMID 18753194, Free PMC Article
    3. Protein O-mannosyltransferases participate in ER protein quality control. Goder V, et al. J Cell Sci, 2011 Jan 1. PMID 21147851
    4. Deubiquitinating enzymes Ubp2 and Ubp15 regulate endocytosis by limiting ubiquitination and degradation of ARTs. Ho HC, et al. Mol Biol Cell, 2017 May 1. PMID 28298493, Free PMC Article
    5. Four novel suppressors of gic1 gic2 and their roles in cytokinesis and polarized cell growth in Saccharomyces cerevisiae. Gandhi M, et al. Genetics, 2006 Oct. PMID 16816427, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MLF3 regulates polarization of the actin cytoskeleton and cell growth and function in a pathway distinct from and parallel to GIC1 and GIC2.
      Title: Four novel suppressors of gic1 gic2 and their roles in cytokinesis and polarized cell growth in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to heat IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in establishment or maintenance of actin cytoskeleton polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    Mlf3p
    NP_014325.3
    • Serine-rich hypothetical protein; predicted to be palmitoylated; overproduction suppresses growth inhibition caused by exposure to immunosuppressant leflunomide; MLF3 has a paralog, VHS2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      486766..488124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182912.3 → NP_014325.3  TPA: Mlf3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014325.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1A5, P32047
      UniProtKB/TrEMBL
      A6ZS06, N1NXI8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32047.2

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