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    VPS5 sorting nexin 1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854235, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VPS5
    Official Full Name
    sorting nexin 1
    Primary source
    SGD:S000005595
    Locus tag
    YOR069W
    See related
    AllianceGenome:SGD:S000005595; FungiDB:YOR069W; VEuPathDB:YOR069W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    GRD2; PEP10; VPT5
    Summary
    Enables phosphatidylinositol-3-phosphate binding activity. Contributes to cargo adaptor activity. Involved in protein retention in Golgi apparatus and retrograde transport, endosome to Golgi. Located in cytosol and endosome. Part of retromer, tubulation complex. Orthologous to human SNX1 (sorting nexin 1) and SNX2 (sorting nexin 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VPS5 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (453768..455795)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Msa1p Neighboring gene dolichyl-P-Glc:Glc1Man(9)GlcNAc(2)-PP-dolichol alpha-1,3-glucosyltransferase Neighboring gene Vam10p Neighboring gene GTPase-activating protein GYP1 Neighboring gene nicotinamide riboside transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The yeast mutant vps5Delta affected in the recycling of Golgi membrane proteins displays an enhanced vacuolar Mg2+/H+ exchange activity. Borrelly G, et al. Proc Natl Acad Sci U S A, 2001 Aug 14. PMID 11493679, Free PMC Article
    2. Identification of the functional domains of yeast sorting nexins Vps5p and Vps17p. Seaman MN, et al. Mol Biol Cell, 2002 Aug. PMID 12181349, Free PMC Article
    3. The yeast VPS5/GRD2 gene encodes a sorting nexin-1-like protein required for localizing membrane proteins to the late Golgi. Nothwehr SF, et al. J Cell Sci, 1997 May. PMID 9175702
    4. A sorting nexin-1 homologue, Vps5p, forms a complex with Vps17p and is required for recycling the vacuolar protein-sorting receptor. Horazdovsky BF, et al. Mol Biol Cell, 1997 Aug. PMID 9285823, Free PMC Article
    5. N-terminal signals in the SNX-BAR paralogs Vps5 and Vin1 guide endosomal coat complex formation. Shortill SP, et al. Mol Biol Cell, 2024 Jun 1. PMID 38598303, Free PMC Article

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to cargo adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to cargo adaptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3-phosphate binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphatidylinositol-3-phosphate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein retention in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein retention in Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde transport, endosome to Golgi IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of retromer complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of retromer complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of retromer, tubulation complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sorting nexin 1
    NP_014712.2
    • Nexin-1 homolog; required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to late Golgi; structural component of retromer membrane coat complex; forms a retromer subcomplex with Vps17p; required for recruiting the retromer complex to the endosome membranes; VPS5 has a paralog, YKR078W, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      453768..455795
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183488.1 → NP_014712.2  TPA: sorting nexin 1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014712.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2D1, E9P8U6, Q08483, Q92331
      UniProtKB/TrEMBL
      A6ZNS0, B3LJB7, B5VRW7, C8ZI29, G2WMU6, N1NWW5
      Conserved Domains (2) summary
      cd06861
      Location:281 → 390
      PX_Vps5p; The phosphoinositide binding Phox Homology domain of yeast sorting nexin Vps5p
      cd07627
      Location:460 → 673
      BAR_Vps5p; The Bin/Amphiphysin/Rvs (BAR) domain of yeast Sorting Nexin Vps5p
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92331.1

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