Cmklr1 chemerin chemokine-like receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cmklr1provided by MGI
Official Full Name: chemerin chemokine-like receptor 1provided by MGI
Primary source: MGI:MGI:109603
See related: Ensembl:ENSMUSG00000042190 AllianceGenome:MGI:109603
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DEZ; Gpcr27; ChemR23; mcmklr1
Summary: Predicted to enable adipokinetic hormone binding activity; adipokinetic hormone receptor activity; and transmembrane signaling receptor activity. Involved in negative regulation of interleukin-12 production; positive regulation of cold-induced thermogenesis; and positive regulation of fat cell differentiation. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; embryo mesenchyme; jaw; lung; and uterus. Orthologous to human CMKLR1 (chemerin chemokine-like receptor 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in lung adult (RPKM 58.5), subcutaneous fat pad adult (RPKM 38.4) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 55.55 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (113750415..113792971, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (113612355..113650475, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection.
Title: The chemerin-CMKLR1 axis in keratinocytes impairs innate host defense against cutaneous Staphylococcus aureus infection.
ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke.
Title: ChemR23 signaling ameliorates brain injury via inhibiting NLRP3 inflammasome-mediated neuronal pyroptosis in ischemic stroke.
Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice.
Title: Resolvin E1/ChemR23 Protects Against Hypertension and Vascular Remodeling in Angiotensin II-Induced Hypertensive Mice.
miR-22-3p ameliorates the symptoms of premature ovarian failure in mice by inhibiting CMKLR1 expression.
Title: miR-22-3p ameliorates the symptoms of premature ovarian failure in mice by inhibiting CMKLR1 expression.
n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.
Title: n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout.
The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease.
Title: The chemerin/CMKLR1 axis regulates intestinal graft-versus-host disease.
Chemokine-like receptor 1 deficiency impedes macrophage phenotypic transformation and cardiac repair after myocardial infarction.
Title: Chemokine-like receptor 1 deficiency impedes macrophage phenotypic transformation and cardiac repair after myocardial infarction.
ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation.
Title: ChemR23 signaling ameliorates cognitive impairments in diabetic mice via dampening oxidative stress and NLRP3 inflammasome activation.
The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Abeta Deposition through p38 MAPK Pathway.
Title: The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Aβ Deposition through p38 MAPK Pathway.
Epithelial chemerin-CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase.
Title: Epithelial chemerin-CMKLR1 signaling restricts microbiota-driven colonic neutrophilia and tumorigenesis by up-regulating lactoperoxidase.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

U79525 (e-PCR)
- UniSTS:163369

AU048745 (e-PCR)
- UniSTS:145195

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables adipokinetic hormone binding	ISO Inferred from Sequence Orthology more info
enables adipokinetic hormone binding	ISS Inferred from Sequence or Structural Similarity more info
enables adipokinetic hormone receptor activity	ISO Inferred from Sequence Orthology more info
enables adipokinetic hormone receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables complement receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in G protein-coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in complement receptor mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of interleukin-12 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: chemerin-like receptor 1

Names: G-protein coupled receptor 27; G-protein coupled receptor DEZ; chemerin receptor; chemokine receptor-like 1; chemokine-like receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359060.1 → NP_001345989.1 chemerin-like receptor 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC241893, CJ072893

Consensus CDS

CCDS19551.1

UniProtKB/Swiss-Prot

P97468

UniProtKB/TrEMBL

E9Q8N2, Q497D3

Conserved Domains (1) summary

cd15116
Location:39 → 325

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_008153.3 → NP_032179.1 chemerin-like receptor 1

See identical proteins and their annotated locations for NP_032179.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC241893, BY347978

Consensus CDS

CCDS19551.1

UniProtKB/Swiss-Prot

P97468

UniProtKB/TrEMBL

E9Q8N2, Q497D3

Related

ENSMUSP00000036316.7, ENSMUST00000047936.13

Conserved Domains (1) summary

cd15116
Location:39 → 325

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

113750415..113792971 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164795.1 → XP_036020688.1 chemerin-like receptor 1 isoform X1

UniProtKB/Swiss-Prot

P97468

UniProtKB/TrEMBL

E9Q8N2, Q497D3

Conserved Domains (1) summary

cd15116
Location:39 → 325

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006530164.5 → XP_006530227.1 chemerin-like receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006530227.1

UniProtKB/Swiss-Prot

P97468

UniProtKB/TrEMBL

E9Q8N2, Q497D3

Conserved Domains (1) summary

cd15116
Location:39 → 325

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006530166.3 → XP_006530229.1 chemerin-like receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006530229.1

UniProtKB/Swiss-Prot

P97468

UniProtKB/TrEMBL

E9Q8N2, Q497D3

Related

ENSMUSP00000121765.2, ENSMUST00000132065.8

Conserved Domains (1) summary

cd15116
Location:39 → 325

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_006530165.4 → XP_006530228.1 chemerin-like receptor 1 isoform X1

See identical proteins and their annotated locations for XP_006530228.1

UniProtKB/Swiss-Prot

P97468

UniProtKB/TrEMBL

E9Q8N2, Q497D3

Conserved Domains (1) summary

cd15116
Location:39 → 325

7tmA_CMKLR1; chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors