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    VFA1 Vfa1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856865, updated on 9-Dec-2024

    Summary

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    Official Symbol
    VFA1
    Official Full Name
    Vfa1p
    Primary source
    SGD:S000000930
    Locus tag
    YER128W
    See related
    AllianceGenome:SGD:S000000930; FungiDB:YER128W; VEuPathDB:YER128W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ATPase activator activity. Involved in vacuolar transport. Located in endosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See VFA1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (415859..416470)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene rRNA-processing protein NSA2 Neighboring gene Lcp5p Neighboring gene serine/threonine protein kinase SAK1 Neighboring gene Com2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Vfa1 binds to the N-terminal microtubule-interacting and trafficking (MIT) domain of Vps4 and stimulates its ATPase activity. Vild CJ, et al. J Biol Chem, 2014 Apr 11. PMID 24567329, Free PMC Article
    2. Structural Fine-Tuning of MIT-Interacting Motif 2 (MIM2) and Allosteric Regulation of ESCRT-III by Vps4 in Yeast. Kojima R, et al. J Mol Biol, 2016 Jun 5. PMID 27075672
    3. Spatiotemporal dynamics of membrane remodeling and fusion proteins during endocytic transport. Arlt H, et al. Mol Biol Cell, 2015 Apr 1. PMID 25657322, Free PMC Article
    4. An overexpression screen in Saccharomyces cerevisiae identifies novel genes that affect endocytic protein trafficking. Arlt H, et al. Traffic, 2011 Nov. PMID 21777356
    5. A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging. McCormick MA, et al. Cell Metab, 2015 Nov 3. PMID 26456335, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Vfa1 is a novel positive regulator of Vps4 function
      Title: Vfa1 binds to the N-terminal microtubule-interacting and trafficking (MIT) domain of Vps4 and stimulates its ATPase activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuolar transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuolar transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Vfa1p
    NP_011054.3
    • Protein that interacts with Vps4p and has a role in vacuolar sorting; stimulates the ATPase activity of Vps4; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      415859..416470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179018.3 → NP_011054.3  TPA: Vfa1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011054.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM34, P40080
      UniProtKB/TrEMBL
      A6ZR82, B3LRP4, B5VHQ6, C7GKX5, C8Z7E5, G2WCZ7, N1P3K4
      Conserved Domains (1) summary
      pfam08432
      Location:3 → 203
      Vfa1; AAA-ATPase Vps4-associated protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40080.1

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