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    TRR2 thioredoxin-disulfide reductase TRR2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856506, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TRR2
    Official Full Name
    thioredoxin-disulfide reductase TRR2
    Primary source
    SGD:S000001148
    Locus tag
    YHR106W
    See related
    AllianceGenome:SGD:S000001148; FungiDB:YHR106W; VEuPathDB:YHR106W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables thioredoxin-disulfide reductase (NADPH) activity. Involved in cellular response to oxidative stress. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TRR2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (325598..326626)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene trifunctional aldehyde reductase/xylose reductase/glucose 1-dehydrogenase (NADP(+)) Neighboring gene Ypt35p Neighboring gene septin CDC12 Neighboring gene phosphatidylinositol 4-phosphate-binding protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial and nuclear localization of a novel pea thioredoxin: identification of its mitochondrial target proteins. Martí MC, et al. Plant Physiol, 2009 Jun. PMID 19363090, Free PMC Article
    2. Thioredoxin-dependent peroxide reductase from yeast. Chae HZ, et al. J Biol Chem, 1994 Nov 4. PMID 7961686
    3. Mitochondria of Saccharomyces cerevisiae contain one-conserved cysteine type peroxiredoxin with thioredoxin peroxidase activity. Pedrajas JR, et al. J Biol Chem, 2000 May 26. PMID 10821871
    4. Crystal structure of Saccharomyces cerevisiae cytoplasmic thioredoxin reductase Trr1 reveals the structural basis for species-specific recognition of thioredoxin. Zhang Z, et al. Biochim Biophys Acta, 2009 Jan. PMID 18930846
    5. Activation of translation via reduction by thioredoxin-thioredoxin reductase in Saccharomyces cerevisiae. Jun KO, et al. FEBS Lett, 2009 Sep 3. PMID 19622355

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results suggest that redox control via the thioredoxin-thioredoxin reductase 1/2 system plays an important role in the regulation of translation.
      Title: Activation of translation via reduction by thioredoxin-thioredoxin reductase in Saccharomyces cerevisiae.
    2. The yeast mitochondrial 1-Cys Prx1 is reactivated by glutathionylation of the catalytic cysteine residue and subsequent reduction by thioredoxin reductase (Trr2) coupled with glutathione (GSH).
      Title: Antioxidant activity of the yeast mitochondrial one-Cys peroxiredoxin is dependent on thioredoxin reductase and glutathione in vivo.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thioredoxin-disulfide reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in removal of superoxide radicals IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin-disulfide reductase TRR2
    NP_011974.1
    • Mitochondrial thioredoxin reductase; involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD; TRR2 has a paralog, TRR1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      325598..326626
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179236.1 → NP_011974.1  TPA: thioredoxin-disulfide reductase TRR2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011974.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL56, P38816
      UniProtKB/TrEMBL
      A6ZT14, B3LSM1, B5VK41, C7GLZ2, C8Z9P9, G2WFI0, N1P2R5
      Conserved Domains (1) summary
      TIGR01292
      Location:28 → 338
      TRX_reduct; thioredoxin-disulfide reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38816.1

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