AMN1 Amn1p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: AMN1
Official Full Name: Amn1p
Primary source: SGD:S000000362
Locus tag: YBR158W
See related: AllianceGenome:SGD:S000000362; FungiDB:YBR158W; VEuPathDB:YBR158W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CST13; ICS4
Summary: Enables small GTPase binding activity. Involved in several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; negative regulation of mitotic cell cycle phase transition; and negative regulation of septum digestion after cytokinesis. Located in cellular bud; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

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Downregulation of the Tem1 GTPase by Amn1 after cytokinesis involves both nuclear import and SCF-mediated degradation.
Title: Downregulation of the Tem1 GTPase by Amn1 after cytokinesis involves both nuclear import and SCF-mediated degradation.
The Cbk1-Ace2 axis guides Candida albicans from yeast to hyphae and back again.
Title: The Cbk1-Ace2 axis guides Candida albicans from yeast to hyphae and back again.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle orientation checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of exit from mitosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of septum digestion after cytokinesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of septum digestion after cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex disassembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cellular bud	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_009716.1

Modulator of cell separation and mitotic exit; inhibits separation through Ub-dependent Ace2p proteolysis; part of a daughter-specific switch induced by the mitotic exit network that inhibits exit and resets the cell cycle after the execution of MEN function, blocking Tem1p and Cdc15 association; required for chromosome stability and multiple mitotic checkpoints; regulated by SCF; haploid transcription regulated by Ste12p; contains 12 degenerate leucine-rich repeat motifs and an atypical F-box

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The following sections contain reference sequences that belong to a specific genome build. Explain