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    COX19 Cox19p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850642, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COX19
    Official Full Name
    Cox19p
    Primary source
    SGD:S000007245
    Locus tag
    YLL018C-A
    See related
    AllianceGenome:SGD:S000007245; FungiDB:YLL018C-A; VEuPathDB:YLL018C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables copper ion binding activity. Involved in metal ion transport and mitochondrial cytochrome c oxidase assembly. Located in cytosol and mitochondrial intermembrane space. Orthologous to human COX19 (cytochrome c oxidase assembly factor COX19). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COX19 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (108676..108972, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Spa2p Neighboring gene serine/threonine protein kinase KNS1 Neighboring gene aspartate--tRNA ligase DPS1 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. characterization of the cytochrome c oxidase assembly factor Cox19 of Saccharomyces cerevisiae. Rigby K, et al. J Biol Chem, 2007 Apr 6. PMID 17237235
    2. The mitochondrial intermembrane space oxireductase Mia40 funnels the oxidative folding pathway of the cytochrome c oxidase assembly protein Cox19. Fraga H, et al. J Biol Chem, 2014 Apr 4. PMID 24569988, Free PMC Article
    3. Characterization of COX19, a widely distributed gene required for expression of mitochondrial cytochrome oxidase. Nobrega MP, et al. J Biol Chem, 2002 Oct 25. PMID 12171940
    4. Redox-regulated dynamic interplay between Cox19 and the copper-binding protein Cox11 in the intermembrane space of mitochondria facilitates biogenesis of cytochrome c oxidase. Bode M, et al. Mol Biol Cell, 2015 Jul 1. PMID 25926683, Free PMC Article
    5. Characterization of Arabidopsis thaliana genes encoding functional homologues of the yeast metal chaperone Cox19p, involved in cytochrome c oxidase biogenesis. Attallah CV, et al. Plant Mol Biol, 2007 Oct. PMID 17712601

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mitochondrial intermembrane space oxireductase Mia40 funnels the oxidative folding pathway of the cytochrome c oxidase assembly protein Cox19
      Title: The mitochondrial intermembrane space oxireductase Mia40 funnels the oxidative folding pathway of the cytochrome c oxidase assembly protein Cox19.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in metal ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitochondrial cytochrome c oxidase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial cytochrome c oxidase assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Cox19p
    NP_013082.1
    • Protein required for cytochrome c oxidase assembly; located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      108676..108972 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184338.1 → NP_013082.1  TPA: Cox19p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013082.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXY5, Q3E731
      UniProtKB/TrEMBL
      A7A0N8, B3LTF1, C7GPH4, C8ZCV5, G2WIH6, N1NZQ3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3E731.1

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