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    NNR1 NADHX epimerase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855521, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NNR1
    Official Full Name
    NADHX epimerase
    Primary source
    SGD:S000005144
    Locus tag
    YNL200C
    See related
    AllianceGenome:SGD:S000005144; FungiDB:YNL200C; VEuPathDB:YNL200C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables NAD(P)HX epimerase activity. Involved in nicotinamide nucleotide metabolic process. Located in mitochondrion. Orthologous to several human genes including NAXE (NAD(P)HX epimerase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NNR1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (263713..264453, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene 2,4-dienoyl-CoA reductase (NADPH) Neighboring gene Psy2p Neighboring gene Gcr2p Neighboring gene mRNA-binding protein WHI3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair. Marbaix AY, et al. J Biol Chem, 2011 Dec 2. PMID 21994945, Free PMC Article
    2. Stress response and expression patterns in wine fermentations of yeast genes induced at the diauxic shift. Puig S, et al. Yeast, 2000 Jan 30. PMID 10641036
    3. Genomic expression program involving the Haa1p-regulon in Saccharomyces cerevisiae response to acetic acid. Mira NP, et al. OMICS, 2010 Oct. PMID 20955010, Free PMC Article
    4. Genetic basis for Saccharomyces cerevisiae biofilm in liquid medium. Scherz K, et al. G3 (Bethesda), 2014 Jul 9. PMID 25009170, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications. Philippsen P, et al. Nature, 1997 May 29. PMID 9169873

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables NAD(P)HX epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD(P)HX epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables NAD(P)HX epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nicotinamide nucleotide metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NADHX epimerase
    NP_014199.1
    • NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      263713..264453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183038.1 → NP_014199.1  TPA: NADHX epimerase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014199.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0Y8, P40165
      UniProtKB/TrEMBL
      A6ZRN8, B3LP46, B5VQL0, C7GTH0, C8ZG31, G2WLR1, N1P452
      Conserved Domains (1) summary
      TIGR00197
      Location:5 → 224
      yjeF_nterm; yjeF N-terminal region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40165.1

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