BUL1 ubiquitin-ubiquitin ligase BUL1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BUL1
Official Full Name: ubiquitin-ubiquitin ligase BUL1
Primary source: SGD:S000004888
Locus tag: YMR275C
See related: AllianceGenome:SGD:S000004888; FungiDB:YMR275C; VEuPathDB:YMR275C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: DAG1; RDS1; SMM2
Summary: Enables ubiquitin-ubiquitin ligase activity. Involved in several processes, including ATP export; mitochondrion inheritance; and protein ubiquitination. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See BUL1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (815651..818581, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Downregulation of the broad-specificity amino acid permease Agp1 mediated by the ubiquitin ligase Rsp5 and the arrestin-like protein Bul1 in yeast.
Title: Downregulation of the broad-specificity amino acid permease Agp1 mediated by the ubiquitin ligase Rsp5 and the arrestin-like protein Bul1 in yeast.
employment of specific inactive Jen1p versions showed that Bul1p-dependent endocytosis requires lactate transport, according to the signal imposed
Title: The α-Arrestin Bul1p Mediates Lactate Transporter Endocytosis in Response to Alkalinization and Distinct Physiological Signals.
Mutations in Rsp5p-Bul1-Bil2p ubiquitin ligase complex favors initial growth of autotrophic in synthetic grape must.
Title: An impaired ubiquitin ligase complex favors initial growth of auxotrophic yeast strains in synthetic grape must.
While rsp5(T255A), RSP5(T357A), and rsp5(T413A) impaired the interaction of Rsp5 with Bul1, the RSP5(T357A) mutation specifically augmented the interaction with Bul2.
Title: Cooperative and selective roles of the WW domains of the yeast Nedd4-like ubiquitin ligase Rsp5 in the recognition of the arrestin-like adaptors Bul1 and Bul2.
Internal amino acids promote Gap1 permease ubiquitylation via TORC1/Npr1/14-3-3-dependent control of the Bul arrestin-like adaptors.
Title: Internal amino acids promote Gap1 permease ubiquitylation via TORC1/Npr1/14-3-3-dependent control of the Bul arrestin-like adaptors.
Gln3-mediated transcription activated by nitrogen signal transduction is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae
Title: Transduction of the nitrogen signal activating Gln3-mediated transcription is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ubiquitin-ubiquitin ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-ubiquitin ligase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrion inheritance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein monoubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein monoubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein polyubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in response to glucose	IGI Inferred from Genetic Interaction more info	PubMed
involved_in ubiquitin-dependent endocytosis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ubiquitin-ubiquitin ligase BUL1

NP_014002.1

Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex; ubiquitin-binding adaptor involved in down-regulation of general amino acid transporter Gap1p upon shift to preferred nitrogen source; involved in lactate transporter Jen1p endocytosis; BUL1 has a paralog, BUL2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

815651..818581 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182782.1 → NP_014002.1 TPA: ubiquitin-ubiquitin ligase BUL1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014002.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0A2, P48524

UniProtKB/TrEMBL

B3LMG3, C7GTM4, C8ZFE2

Conserved Domains (2) summary

pfam04426
Location:690 → 974

Bul1_C; Bul1 C-terminus

pfam04425
Location:108 → 543

Bul1_N; Bul1 N-terminus