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    PRP4 U4/U6-U5 snRNP complex subunit PRP4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856307, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PRP4
    Official Full Name
    U4/U6-U5 snRNP complex subunit PRP4
    Primary source
    SGD:S000006382
    Locus tag
    YPR178W
    See related
    AllianceGenome:SGD:S000006382; FungiDB:YPR178W; VEuPathDB:YPR178W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RNA4
    Summary
    Predicted to enable U4 snRNA binding activity and U6 snRNA binding activity. Involved in snoRNA splicing and spliceosomal conformational changes to generate catalytic conformation. Part of U4/U6 x U5 tri-snRNP complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 70. Orthologous to human PRPF4 (pre-mRNA splicing tri-snRNP complex factor PRPF4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PRP4 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (892332..893729)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene DNA polymerase epsilon noncatalytic subunit Neighboring gene Rab geranylgeranyltransferase BET2 Neighboring gene Hda3p Neighboring gene E1 ubiquitin-activating protein AOS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Domains of yeast U4 spliceosomal RNA required for PRP4 protein binding, snRNP-snRNP interactions, and pre-mRNA splicing in vivo. Bordonné R, et al. Genes Dev, 1990 Jul. PMID 2145195
    2. PRP4 (RNA4) from Saccharomyces cerevisiae: its gene product is associated with the U4/U6 small nuclear ribonucleoprotein particle. Bjørn SP, et al. Mol Cell Biol, 1989 Sep. PMID 2528686, Free PMC Article
    3. Mutational analysis of the PRP4 protein of Saccharomyces cerevisiae suggests domain structure and snRNP interactions. Hu J, et al. Nucleic Acids Res, 1994 May 11. PMID 8202378, Free PMC Article
    4. PRP4: a protein of the yeast U4/U6 small nuclear ribonucleoprotein particle. Banroques J, et al. Mol Cell Biol, 1989 Sep. PMID 2528687, Free PMC Article
    5. Mutations within the yeast U4/U6 snRNP protein Prp4 affect a late stage of spliceosome assembly. Ayadi L, et al. RNA, 1997 Feb. PMID 9042946, Free PMC Article

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables U4 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables U6 snRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snoRNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spliceosomal conformational changes to generate catalytic conformation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U4/U6 x U5 tri-snRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U4/U6 x U5 tri-snRNP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U4/U6-U5 snRNP complex subunit PRP4
    NP_015504.1
    • Splicing factor; component of the U4/U6-U5 snRNP complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      892332..893729
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184275.1 → NP_015504.1  TPA: U4/U6-U5 snRNP complex subunit PRP4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015504.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4H8, P20053
      UniProtKB/TrEMBL
      B3LKD7, B5VTV9, C8ZJK7
      Conserved Domains (3) summary
      cd00200
      Location:175 → 465
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:178 → 216
      7WD40; WD40 repeat [structural motif]
      pfam16515
      Location:128 → 175
      HIP1_clath_bdg; Clathrin-binding domain of Huntingtin-interacting protein 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20053.1

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