ULP2 SUMO protease ULP2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: ULP2
Official Full Name: SUMO protease ULP2
Primary source: SGD:S000001293
Locus tag: YIL031W
See related: AllianceGenome:SGD:S000001293; FungiDB:YIL031W; VEuPathDB:YIL031W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SMT4
Summary: Enables deSUMOylase activity and transcription elongation factor activity. Involved in several processes, including mitotic spindle assembly checkpoint signaling; plasmid maintenance; and protein desumoylation. Located in chromatin and nucleus. Used to study acute promyelocytic leukemia. Orthologous to human SENP7 (SUMO specific peptidase 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ULP2 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (292633..295737)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore.
Title: Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore.
These results indicate that Ulp2 utilizes its dual substrate recognition to prevent hyper-sumoylation of Constitutive Centromere-Associated Network, ensuring accurate chromosome segregation during cell division.
Title: Recruitment of the Ulp2 protease to the inner kinetochore prevents its hyper-sumoylation to ensure accurate chromosome segregation.
Results suggest sequential ubiquitin-histone and SUMO-histone modifications recruit Ulp2, which removes polySUMO chains and promotes RNAPII transcription elongation.
Title: The Ulp2 SUMO protease promotes transcription elongation through regulation of histone sumoylation.
Aneuploidy allows rapid adaptation to Ulp2 loss, but long-term adaptation restores euploidy.
Title: Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease.
Binding to Csm1 regulates substrate specificity of the Ulp2 protease.
Title: Binding to small ubiquitin-like modifier and the nucleolar protein Csm1 regulates substrate specificity of the Ulp2 protease.
Ulp2 promotes rDNA silencing by opposing STUbL-mediated degradation of silencing proteins
Title: Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity.
Extra copies of ChrI and ChrXII appear quickly following loss of active Ulp2 and can be eliminated following reintroduction of ULP2, suggesting that aneuploidy is a reversible adaptive mechanism to counteract loss of the SUMO protease
Title: Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy.
Ulp2 controls the dynamic range of SUMO chain lengths by trimming them from the distal ends
Title: In Vitro Studies Reveal a Sequential Mode of Chain Processing by the Yeast SUMO (Small Ubiquitin-related Modifier)-specific Protease Ulp2.
mis-regulation is accompanied by a severe, recombination-dependent, block to chromosome segregation, revealing a critical role for Ulp2p in allowing sister chromatids to disjoin following HR DNA repair.
Title: The SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stress.
C-terminal region of Ulp2 is phosphorylated during mitosis in a Cdc5-dependent manner.
Title: The yeast SUMO isopeptidase Smt4/Ulp2 and the polo kinase Cdc5 act in an opposing fashion to regulate sumoylation in mitosis and cohesion at centromeres.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables cysteine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables deSUMOylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deSUMOylase activity	IDA Inferred from Direct Assay more info	PubMed
enables deSUMOylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transcription elongation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-like protein peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromosome condensation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasmid maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein desumoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein desumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein desumoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SUMO protease ULP2

NP_012233.1

Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins; plays a role in chromosome cohesion at centromeric regions, recovery from checkpoint arrest induced by DNA damage or DNA replication defect, and RNA splicing; potential Cdc28p substrate; human homolog PML implicated in promyelocytic leukemia can partially complement yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

292633..295737

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179381.1 → NP_012233.1 TPA: SUMO protease ULP2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012233.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVQ0, P40537

UniProtKB/TrEMBL

A6ZVN7, B3LTN7, C7GVW0, C8ZAL5, N1P0M7

Conserved Domains (1) summary

COG5160
Location:45 → 695

ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]