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    AEP3 Aep3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856102, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AEP3
    Official Full Name
    Aep3p
    Primary source
    SGD:S000005926
    Locus tag
    YPL005W
    See related
    AllianceGenome:SGD:S000005926; FungiDB:YPL005W; VEuPathDB:YPL005W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable mRNA binding activity. Involved in mitochondrial translational initiation. Acts upstream of or within mRNA metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AEP3 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (548486..550306)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene transcription factor TFIIIC subunit TFC8 Neighboring gene sphingolipid transporter Neighboring gene lipid-binding protein LSP1 Neighboring gene Ula1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Aep3p-dependent translation of yeast mitochondrial ATP8. Barros MH, et al. Mol Biol Cell, 2017 Jun 1. PMID 28404747, Free PMC Article
    2. Aep3p stabilizes the mitochondrial bicistronic mRNA encoding subunits 6 and 8 of the H+-translocating ATP synthase of Saccharomyces cerevisiae. Ellis TP, et al. J Biol Chem, 2004 Apr 16. PMID 14742425
    3. Yeast AEP3p is an accessory factor in initiation of mitochondrial translation. Lee C, et al. J Biol Chem, 2009 Dec 4. PMID 19843529, Free PMC Article
    4. Efficient construction of homozygous diploid strains identifies genes required for the hyper-filamentous phenotype in Saccharomyces cerevisiae. Furukawa K, et al. PLoS One, 2011. PMID 22039512, Free PMC Article
    5. Analysis of the vacuolar luminal proteome of Saccharomyces cerevisiae. Sarry JE, et al. FEBS J, 2007 Aug. PMID 17651441

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aep3p functions as an accessory initiation factor in mitochondrial protein synthesis
      Title: Yeast AEP3p is an accessory factor in initiation of mitochondrial translation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial translational initiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Aep3p
    NP_015320.1
    • Peripheral mitochondrial inner membrane protein; may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; stabilizes the bicistronic AAP1-ATP6 mRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      548486..550306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183819.1 → NP_015320.1  TPA: Aep3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015320.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W407, Q12089
      UniProtKB/TrEMBL
      A6ZWP1, N1NVI9
      Conserved Domains (1) summary
      sd00004
      Location:223 → 250
      PPR; PPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12089.1

    Gene LinkOut

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