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    REX3 RNA exonuclease [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850797, updated on 9-Dec-2024

    Summary

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    Official Symbol
    REX3
    Official Full Name
    RNA exonuclease
    Primary source
    SGD:S000004097
    Locus tag
    YLR107W
    See related
    AllianceGenome:SGD:S000004097; FungiDB:YLR107W; VEuPathDB:YLR107W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 3'-5'-RNA exonuclease activity. Involved in U5 snRNA 3'-end processing; exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and regulatory ncRNA 3'-end processing. Located in cytoplasm and nucleus. Orthologous to several human genes including REXO1L1P (REXO1 like 1, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See REX3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (364116..365330)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene AAA family ATPase midasin Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Rtr1p CTD phosphatase autoregulates its mRNA through a degradation pathway involving the REX exonucleases. Hodko D, et al. RNA, 2016 Apr. PMID 26843527, Free PMC Article
    2. Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast. van Hoof A, et al. EMBO J, 2000 Mar 15. PMID 10716935, Free PMC Article
    3. Exonucleolysis is required for nuclear mRNA quality control in yeast THO mutants. Assenholt J, et al. RNA, 2008 Nov. PMID 18824516, Free PMC Article
    4. A novel plasmid-based microarray screen identifies suppressors of rrp6Delta in Saccharomyces cerevisiae. Abruzzi K, et al. Mol Cell Biol, 2007 Feb. PMID 17101774, Free PMC Article
    5. The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains. Moser MJ, et al. Nucleic Acids Res, 1997 Dec 15. PMID 9396823, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables 3'-5'-RNA exonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in U5 snRNA 3'-end processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in rRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulatory ncRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA exonuclease
    NP_013208.1
    • RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      364116..365330
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181994.1 → NP_013208.1  TPA: RNA exonuclease [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013208.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYA7, Q12090, Q7LI70
      UniProtKB/TrEMBL
      A7A111, B3LT74, C7GQS9, C8ZD78, N1NZL9
      Conserved Domains (1) summary
      cd06145
      Location:244 → 390
      REX1_like; DEDDh 3'-5' exonuclease domain of RNA exonuclease 1, -3 and similar eukaryotic proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12090.1

    Gene LinkOut

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