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    GID10 Gid10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852957, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GID10
    Official Full Name
    Gid10p
    Primary source
    SGD:S000003298
    Locus tag
    YGR066C
    See related
    AllianceGenome:SGD:S000003298; FungiDB:YGR066C; VEuPathDB:YGR066C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein catabolic process; response to osmotic stress; and response to starvation. Part of GID complex. Orthologous to human GID4 (GID complex subunit 4 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GID10 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (620921..621799, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene transcription elongation factor SPT4 Neighboring gene Vht1p Neighboring gene uncharacterized protein Neighboring gene Art5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of yeast Gid10 in complex with Pro/N-degron. Shin JS, et al. Biochem Biophys Res Commun, 2021 Dec 10. PMID 34695755
    2. Vid24p, a novel protein localized to the fructose-1, 6-bisphosphatase-containing vesicles, regulates targeting of fructose-1,6-bisphosphatase from the vesicles to the vacuole for degradation. Chiang MC, et al. J Cell Biol, 1998 Mar 23. PMID 9508768, Free PMC Article
    3. Gid10 as an alternative N-recognin of the Pro/N-degron pathway. Melnykov A, et al. Proc Natl Acad Sci U S A, 2019 Aug 6. PMID 31337681, Free PMC Article
    4. A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters. Langlois CR, et al. EMBO Rep, 2022 Jun 7. PMID 35437932, Free PMC Article
    5. Defining the specificity of cotranslationally acting chaperones by systematic analysis of mRNAs associated with ribosome-nascent chain complexes. del Alamo M, et al. PLoS Biol, 2011 Jul. PMID 21765803, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Crystal structure of yeast Gid10 in complex with Pro/N-degron.
      Title: Crystal structure of yeast Gid10 in complex with Pro/N-degron.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of gluconeogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein catabolic process in the vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of GID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Gid10p
    NP_011580.3
    • Recognition component (N-recognin) of the Pro/N-degron pathway; recognizes and targets for degradation proteins with N-terminal degradation signals; expressed only under starvation or osmotic stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      620921..621799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181195.3 → NP_011580.3  TPA: Gid10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011580.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUK0, P53242, Q45U21, Q6B2W2
      UniProtKB/TrEMBL
      A6ZV50, B3LIF8, C7GXP8, C8Z8W0, G2WEF2, N1P260
      Conserved Domains (1) summary
      COG5073
      Location:1 → 288
      VID24; Vacuolar import and degradation protein [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53242.1

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