SIN4 Sin4p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SIN4
Official Full Name: Sin4p
Primary source: SGD:S000005180
Locus tag: YNL236W
See related: AllianceGenome:SGD:S000005180; FungiDB:YNL236W; VEuPathDB:YNL236W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: BEL2; GAL22; MED16; RYE1; SDI3; SSF5; SSN4; SSX3; TSF3
Summary: Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including RNA polymerase II preinitiation complex assembly; regulation of establishment of protein localization to chromosome; and regulation of transcription by RNA polymerase II. Part of core mediator complex and mediator complex. [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Connection of core and tail Mediator modules restrains transcription from TFIID-dependent promoters.
Title: Connection of core and tail Mediator modules restrains transcription from TFIID-dependent promoters.
Mediator recruitment to heat shock genes requires dual Hsf1 activation domains and mediator tail subunits Med15 and Med16.
Title: Mediator recruitment to heat shock genes requires dual Hsf1 activation domains and mediator tail subunits Med15 and Med16.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RNA polymerase II preinitiation complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to heat	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of establishment of protein localization to chromosome	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of establishment of protein localization to chromosome	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of core mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
part_of mediator complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_014163.1

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both positive and negative transcriptional regulation; dispensible for basal transcription

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The following sections contain reference sequences that belong to a specific genome build. Explain