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    ARG4 argininosuccinate lyase ARG4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856411, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ARG4
    Official Full Name
    argininosuccinate lyase ARG4
    Primary source
    SGD:S000001060
    Locus tag
    YHR018C
    See related
    AllianceGenome:SGD:S000001060; FungiDB:YHR018C; VEuPathDB:YHR018C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables argininosuccinate lyase activity. Involved in arginine biosynthetic process via ornithine. Located in cytosol. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and argininosuccinic aciduria. Orthologous to human ASL (argininosuccinate lyase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ARG4 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (140011..141402, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Ysc84p Neighboring gene Ysc83p Neighboring gene asparagine--tRNA ligase DED81 Neighboring gene proline--tRNA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA motif associated with meiotic double-strand break regions in Saccharomyces cerevisiae. Blumental-Perry A, et al. EMBO Rep, 2000 Sep. PMID 11256605, Free PMC Article
    2. Timing of molecular events in meiosis in Saccharomyces cerevisiae: stable heteroduplex DNA is formed late in meiotic prophase. Goyon C, et al. Mol Cell Biol, 1993 Jan. PMID 8417336, Free PMC Article
    3. Characterization of a yeast replication origin (ars2) and construction of stable minichromosomes containing cloned yeast centromere DNA (CEN3). Hsiao CL, et al. Gene, 1981 Nov. PMID 7028571
    4. The nucleotide sequence of the yeast ARG4 gene. Beacham IR, et al. Gene, 1984 Sep. PMID 6386606
    5. Genetic recombination of homologous plasmids catalyzed by cell-free extracts of Saccharomyces cerevisiae. Symington LS, et al. Cell, 1983 Dec. PMID 6360380

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gcn4p stimulates binding of Cyc8p/Tup1p at the 3' end of the ARG4 gene.
      Title: Activator Gcn4p and Cyc8p/Tup1p are interdependent for promoter occupancy at ARG1 in vivo.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables argininosuccinate lyase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables argininosuccinate lyase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables argininosuccinate lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginine biosynthetic process via ornithine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arginine biosynthetic process via ornithine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in arginine biosynthetic process via ornithine IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    argininosuccinate lyase ARG4
    NP_011882.1
    • Argininosuccinate lyase; catalyzes the final step in the arginine biosynthesis pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      140011..141402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179148.1 → NP_011882.1  TPA: argininosuccinate lyase ARG4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011882.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKW3, P04076
      UniProtKB/TrEMBL
      A6ZSS2, B5VJU5, C7GXA8, C8ZA85, G2WF86, N1P375
      Conserved Domains (1) summary
      TIGR00838
      Location:8 → 463
      argH; argininosuccinate lyase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P04076.2

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