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    DSC3 Dsc3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    DSC3
    Official Full Name
    Dsc3p
    Primary source
    SGD:S000005749
    Locus tag
    YOR223W
    See related
    AllianceGenome:SGD:S000005749; FungiDB:YOR223W; VEuPathDB:YOR223W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in endocytosis and protein transport. Located in endoplasmic reticulum and fungal-type vacuole lumen. Part of Dsc E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See DSC3 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (759782..760660)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene mitochondrial 2-oxodicarboxylate carrier Neighboring gene ncRNA Neighboring gene DNA-directed RNA polymerase core subunit RPB8 Neighboring gene putative iron-binding protein ISU2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi. Weyer Y, et al. Nat Commun, 2024 Oct 26. PMID 39461958, Free PMC Article
    2. Sequence and analysis of a 33 kb fragment from the right arm of chromosome XV of the yeast Saccharomyces cerevisiae. Galisson F, et al. Yeast, 1996 Jul. PMID 8840505
    3. Identification of candidate substrates for the Golgi Tul1 E3 ligase using quantitative diGly proteomics in yeast. Tong Z, et al. Mol Cell Proteomics, 2014 Nov. PMID 25078903, Free PMC Article
    4. Sorting of a multi-subunit ubiquitin ligase complex in the endolysosome system. Yang X, et al. Elife, 2018 Jan 22. PMID 29355480, Free PMC Article
    5. Membrane-anchored ubiquitin ligase complex is required for the turnover of lysosomal membrane proteins. Li M, et al. J Cell Biol, 2015 Nov 9. PMID 26527740, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Dsc E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Dsc E3 ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Dsc E3 ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Dsc3p
    NP_014866.3
    • Subunit of the DSC ubiquitin ligase complex; hypothetical protein that localizes to the ER and vacuole lumen; overexpression affects endocytic protein trafficking; ortholog of fission yeast dsc3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      759782..760660
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183642.3 → NP_014866.3  TPA: Dsc3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014866.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2S8, Q12015
      UniProtKB/TrEMBL
      A6ZP65, B3LJP6, B5VSA5, C7GWG0, C8ZGX7, G2WN94, N1NWT6
      Conserved Domains (2) summary
      pfam10302
      Location:25 → 125
      DUF2407; DUF2407 ubiquitin-like domain
      pfam13373
      Location:153 → 290
      DUF2407_C; DUF2407 C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12015.1

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