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    RIT1 tRNA A64-2'-O-ribosylphosphate transferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855326, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RIT1
    Official Full Name
    tRNA A64-2'-O-ribosylphosphate transferase
    Primary source
    SGD:S000004896
    Locus tag
    YMR283C
    See related
    AllianceGenome:SGD:S000004896; FungiDB:YMR283C; VEuPathDB:YMR283C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables pentosyltransferase activity. Involved in charged-tRNA amino acid modification. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RIT1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (835326..836867, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene N-acetylglucosaminylphosphatidylinositol deacetylase Neighboring gene Aep2p Neighboring gene tRNA-Tyr Neighboring gene ATP-dependent DNA helicase YKU70

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rit1, a tRNA backbone-modifying enzyme that mediates initiator and elongator tRNA discrimination. Aström SU, et al. Cell, 1994 Nov 4. PMID 7954819
    2. Identification and modeling of a phosphatase-like domain in a tRNA 2'-O-ribosyl phosphate transferase Rit1p. Czerwoniec A, et al. Cell Cycle, 2011 Oct 15. PMID 22030622, Free PMC Article
    3. Global Epitranscriptomics Profiling of RNA Post-Transcriptional Modifications as an Effective Tool for Investigating the Epitranscriptomics of Stress Response. Rose RE, et al. Mol Cell Proteomics, 2016 Mar. PMID 26733207, Free PMC Article
    4. DoMY-Seq: A yeast two-hybrid-based technique for precision mapping of protein-protein interaction motifs. Castel P, et al. J Biol Chem, 2021 Jan-Jun. PMID 33410398, Free PMC Article
    5. Iwr1 protein is important for preinitiation complex formation by all three nuclear RNA polymerases in Saccharomyces cerevisiae. Esberg A, et al. PLoS One, 2011. PMID 21695216, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pentosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pentosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pentosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA adenosine(64)-2'-O-ribosylphosphate transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in charged-tRNA amino acid modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in charged-tRNA amino acid modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in charged-tRNA amino acid modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    tRNA A64-2'-O-ribosylphosphate transferase
    NP_014010.1
    • Initiator methionine 2'-O-ribosyl phosphate transferase; modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      835326..836867 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182790.1 → NP_014010.1  TPA: tRNA A64-2'-O-ribosylphosphate transferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014010.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0B0, P23796
      UniProtKB/TrEMBL
      B3LMH1, C7GTL6, C8ZFF0, N1NZ61
      Conserved Domains (2) summary
      pfam04179
      Location:400 → 512
      Init_tRNA_PT; Rit1 DUSP-like domain
      pfam17184
      Location:35 → 318
      Rit1_C; Rit1 N-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23796.3

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