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    PUG1 Pug1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856934, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PUG1
    Official Full Name
    Pug1p
    Primary source
    SGD:S000000987
    Locus tag
    YER185W
    See related
    AllianceGenome:SGD:S000000987; FungiDB:YER185W; VEuPathDB:YER185W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in heme transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PUG1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (559454..560365)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene 5-formyltetrahydrofolate cyclo-ligase Neighboring gene Tog1p Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loop 5 region is important for the activity of the long-chain base transporter Rsb1. Makuta H, et al. J Biochem, 2017 Feb 1. PMID 28175317
    2. Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiae. Protchenko O, et al. Eukaryot Cell, 2008 May. PMID 18326586, Free PMC Article
    3. Single-Gene Deletions Contributing to Loss of Heterozygosity in Saccharomyces cerevisiae: Genome-Wide Screens and Reproducibility. Hoffert KM, et al. G3 (Bethesda), 2019 Sep 4. PMID 31270132, Free PMC Article
    4. A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease. Giorgini F, et al. Nat Genet, 2005 May. PMID 15806102, Free PMC Article
    5. Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions. Kim H, et al. J Biol Chem, 2003 Mar 21. PMID 12524434

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pug1p induced protoporphyrin IX influx and heme efflux in Saccharomyces cerevisiae.
      Title: Role of PUG1 in inducible porphyrin and heme transport in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pug1p
    NP_011112.3
    • Plasma membrane protein involved in protoprophyrin and heme transport; roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      559454..560365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179075.3 → NP_011112.3  TPA: Pug1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011112.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DM94, P40100
      UniProtKB/TrEMBL
      A6ZRE2, B3LRU5, B5VHW6, C7GUZ1, C8Z7L0, G2WD72, N1P583
      Conserved Domains (1) summary
      pfam04479
      Location:84 → 292
      RTA1; RTA1 like protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40100.1

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