FOX2 bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: FOX2
Official Full Name: bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2
Primary source: SGD:S000001717
Locus tag: YKR009C
See related: AllianceGenome:SGD:S000001717; FungiDB:YKR009C; VEuPathDB:YKR009C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: POX2
Summary: Enables 3-hydroxyacyl-CoA dehydrogenase activity and enoyl-CoA hydratase activity. Involved in fatty acid beta-oxidation. Located in peroxisome. Used to study lipid metabolism disorder. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Orthologous to human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See FOX2 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (454352..457054, complement)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Ile264 amino acid residue in Pex5, which is adjacent to the FxxxW diaromatic domain that was previously shown to be crucial for recognizing AOx and Cat2 as cargos, is also important for the efficient import of Fox2 and Cta1.
Title: The budding yeast Pex5p receptor directs Fox2p and Cta1p into peroxisomes via its N-terminal region near the FxxxW domain.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables (3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables 3-hydroxyacyl-CoA dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-hydroxyacyl-CoA dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables enoyl-CoA hydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables enoyl-CoA hydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	IEA Inferred from Electronic Annotation more info
involved_in fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2

NP_012934.1

EC 1.1.1.n12

EC 4.2.1.119

3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase; multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; mutation is functionally complemented by human HSD17B4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

454352..457054 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179799.1 → NP_012934.1 TPA: bifunctional hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase FOX2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012934.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VX75, Q02207

UniProtKB/TrEMBL

B5VMF8, C7GQF9, G2WI41, N1NZF4

Conserved Domains (4) summary

PLN02864
Location:613 → 886

PLN02864; enoyl-CoA hydratase

cd05353
Location:5 → 255

hydroxyacyl-CoA-like_DH_SDR_c-like; (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs

cd03448
Location:782 → 894

HDE_HSD; HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit.

cl21454
Location:336 → 566

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins