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    PYP1 putative phosphoric monoester hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855722, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PYP1
    Official Full Name
    putative phosphoric monoester hydrolase
    Primary source
    SGD:S000004955
    Locus tag
    YNL010W
    See related
    AllianceGenome:SGD:S000004955; FungiDB:YNL010W; VEuPathDB:YNL010W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphatase activity. Involved in alditol phosphate metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PYP1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (613635..614360)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene putative carboxylic ester hydrolase Neighboring gene uncharacterized protein Neighboring gene isocitrate dehydrogenase (NADP(+)) IDP3 Neighboring gene putative ubiquitin-protein ligase ASI3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Metabolic engineering of the oleaginous yeast Yarrowia lipolytica PO1f for production of erythritol from glycerol. Jagtap SS, et al. Biotechnol Biofuels, 2021 Sep 25. PMID 34563235, Free PMC Article
    2. Discovery and Functional Characterization of a Yeast Sugar Alcohol Phosphatase. Xu YF, et al. ACS Chem Biol, 2018 Oct 19. PMID 30240188, Free PMC Article
    3. The plasma membrane-enriched fraction proteome response during adaptation to hydrogen peroxide in Saccharomyces cerevisiae. Pedroso N, et al. Free Radic Res, 2012 Oct. PMID 22712517
    4. Fungal BLAST and Model Organism BLASTP Best Hits: new comparison resources at the Saccharomyces Genome Database (SGD). Balakrishnan R, et al. Nucleic Acids Res, 2005 Jan 1. PMID 15608219, Free PMC Article
    5. Functional Diversity of Haloacid Dehalogenase Superfamily Phosphatases from Saccharomyces cerevisiae: BIOCHEMICAL, STRUCTURAL, AND EVOLUTIONARY INSIGHTS. Kuznetsova E, et al. J Biol Chem, 2015 Jul 24. PMID 26071590, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-phosphoserine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerol-1-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycerol-1-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerol-3-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribitol-5-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribitol-5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sorbitol-6-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sorbitol-6-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-serine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in alditol phosphate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative phosphoric monoester hydrolase
    NP_014388.3
    • Sugar alcohol phosphatase; polyol phosphatase that hydrolyzes sorbitol-6-phosphate, ribitol-5-phosphate, and (D)-glycerol-3-phosphate, maintaining phosphoglucose isomerase (PGI) activity in the presence of PGI-inhibitory sugar alcohols; expression correlated with growth rate; GFP-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant displays increased glycogen accumulation; member of the haloacid dehalogenase (HAD) superfamily

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      613635..614360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182849.3 → NP_014388.3  TPA: putative phosphoric monoester hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014388.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1G7, P53981
      UniProtKB/TrEMBL
      A6ZS66, B5VR24, C7GJE9, C8ZFL6, G2WL48, N1NXN9
      Conserved Domains (1) summary
      COG4359
      Location:1 → 234
      MtnX; 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase (methionine salvage) [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53981.1

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