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    AAP1 arginine/alanine aminopeptidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856443, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AAP1
    Official Full Name
    arginine/alanine aminopeptidase
    Primary source
    SGD:S000001089
    Locus tag
    YHR047C
    See related
    AllianceGenome:SGD:S000001089; FungiDB:YHR047C; VEuPathDB:YHR047C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AAP1'
    Summary
    Enables aminopeptidase activity. Involved in glycogen metabolic process and proteolysis. Located in cytoplasm and nucleus. Orthologous to several human genes including NPEPPS (aminopeptidase puromycin sensitive). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See AAP1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (198740..201310, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Dde1p Neighboring gene inositol monophosphate 1-phosphatase INM1 Neighboring gene Yhk8p Neighboring gene putative serine hydrolase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and characterization of AAP1. A gene encoding an alanine/arginine aminopeptidase in yeast. Caprioglio DR, et al. J Biol Chem, 1993 Jul 5. PMID 8100228
    2. Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Natarajan K, et al. Mol Cell Biol, 2001 Jul. PMID 11390663, Free PMC Article
    3. Origin, conservation, and loss of alternative splicing events that diversify the proteome in Saccharomycotina budding yeasts. Hurtig JE, et al. RNA, 2020 Oct. PMID 32631843, Free PMC Article
    4. Nuclear Hsp104 safeguards the dormant translation machinery during quiescence. Kohler V, et al. Nat Commun, 2024 Jan 5. PMID 38182580, Free PMC Article
    5. Ribosome-Associated Mba1 Escorts Cox2 from Insertion Machinery to Maturing Assembly Intermediates. Lorenzi I, et al. Mol Cell Biol, 2016 Nov 15. PMID 27550809, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    arginine/alanine aminopeptidase
    NP_011913.1
    • Arginine/alanine amino peptidase; overproduction stimulates glycogen accumulation; AAP1 has a paralog, APE2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      198740..201310 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179177.1 → NP_011913.1  TPA: arginine/alanine aminopeptidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011913.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DKZ5, P37898
      UniProtKB/TrEMBL
      B3LSG6, C7GT86, C8ZAB8, N1P1L5
      Conserved Domains (1) summary
      COG0308
      Location:2 → 844
      PepN; Aminopeptidase N [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37898.2

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