KEX2 kexin KEX2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: KEX2
Official Full Name: kexin KEX2
Primary source: SGD:S000005182
Locus tag: YNL238W
See related: AllianceGenome:SGD:S000005182; FungiDB:YNL238W; VEuPathDB:YNL238W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: QDS1; SRB1; VMA45
Summary: Enables serine-type endopeptidase activity. Involved in peptide pheromone maturation. Located in trans-Golgi network. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; obesity; and proprotein convertase 1/3 deficiency. Orthologous to several human genes including PCSK7 (proprotein convertase subtilisin/kexin type 7). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See KEX2 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (202428..204872)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modulation of Kex2p Cleavage Site for In Vitro Processing of Recombinant Proteins Produced by Saccharomyces cerevisiae.
Title: Modulation of Kex2p Cleavage Site for In Vitro Processing of Recombinant Proteins Produced by Saccharomyces cerevisiae.
Effect of K225 residue to the catalytic efficiency of Kex2 protease.
Title: Effect of K225 residue to the catalytic efficiency of Kex2 protease.
Proteolytic processing by Kex2 of the Saccharomyces cerevisiae cell wall protein Scw4 regulates its activity and influences its covalent binding to glucan.
Title: Proteolytic processing of the Saccharomyces cerevisiae cell wall protein Scw4 regulates its activity and influences its covalent binding to glucan.
Data indicate the substrate specificity of kexin protein(Kex2)using peptides derived from alpha-mating factor.
Title: Specificity characterization of the α-mating factor hormone by Kex2 protease.
Direct binding of the Kex2p cytosolic tail to the VHS domain of yeast Gga2p facilitates trans-Golgi network to prevacuolar compartment transport and is regulated by phosphorylation.
Title: Direct binding of the Kex2p cytosolic tail to the VHS domain of yeast Gga2p facilitates TGN to prevacuolar compartment transport and is regulated by phosphorylation.
KEX2 gene product plays an important role in proliferation of yeast at low temperatures, which is an important trait of bottom-fermenting brewer's yeast.
Title: Role of bottom-fermenting brewer's yeast KEX2 in high temperature resistance and poor proliferation at low temperatures.
Kex2 and Kex1 may promote cell fusion by proteolytically processing substrates that act in parallel to Prm1 as an alternative fusion machine, as cell wall components, or both.
Title: The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating.
Proteolytic cleavage occurs in the first extracellular loop of Gef1p at residues KR136/137 and is carried out by the Kex2p protease
Title: The yeast CLC chloride channel is proteolytically processed by the furin-like protease Kex2p in the first extracellular loop.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peptide pheromone maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in fungal-type vacuole	HDA more info	PubMed
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in trans-Golgi network	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kexin KEX2

NP_014161.1

EC 3.4.21.61

Kexin, a subtilisin-like protease (proprotein convertase); a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

202428..204872

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183076.1 → NP_014161.1 TPA: kexin KEX2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014161.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0V5, P13134

UniProtKB/TrEMBL

B3LP77, C8ZFZ8

Conserved Domains (2) summary

cd04059
Location:133 → 419

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

COG4935
Location:463 → 653

COG4935; Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones]