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    CAF16 putative ATP-binding cassette family ATPase CAF16 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850516, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CAF16
    Official Full Name
    putative ATP-binding cassette family ATPase CAF16
    Primary source
    SGD:S000001866
    Locus tag
    YFL028C
    See related
    AllianceGenome:SGD:S000001866; FungiDB:YFL028C; VEuPathDB:YFL028C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable ATP hydrolysis activity. Involved in regulation of transcription by RNA polymerase II. Located in cytoplasm. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CAF16 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (79344..80213, complement)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene alanine--glyoxylate transaminase Neighboring gene cyclin-dependent protein kinase-activating kinase CAK1 Neighboring gene GTPase-activating protein GYP8 Neighboring gene alpha-factor pheromone receptor STE2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance. Bauer BE, et al. Biochim Biophys Acta, 1999 Dec 6. PMID 10581358
    2. Systematic mutagenesis of the leucine-rich repeat (LRR) domain of CCR4 reveals specific sites for binding to CAF1 and a separate critical role for the LRR in CCR4 deadenylase activity. Clark LB, et al. J Biol Chem, 2004 Apr 2. PMID 14734555
    3. Characterization of CAF4 and CAF16 reveals a functional connection between the CCR4-NOT complex and a subset of SRB proteins of the RNA polymerase II holoenzyme. Liu HY, et al. J Biol Chem, 2001 Mar 9. PMID 11113136
    4. DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex. Mulder KW, et al. Nucleic Acids Res, 2005. PMID 16275785, Free PMC Article
    5. Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex. Mulder KW, et al. Nucleic Acids Res, 2007. PMID 17392337, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of CCR4-NOT complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCR4-NOT complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative ATP-binding cassette family ATPase CAF16
    NP_116625.1
    • Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      79344..80213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179938.1 → NP_116625.1  TPA: putative ATP-binding cassette family ATPase CAF16 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116625.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTK2, P43569
      UniProtKB/TrEMBL
      B3LUI3, B5VI01, C7GY83, C8Z7Q5, G2WDB3, N1P6P1
      Conserved Domains (1) summary
      COG4586
      Location:1 → 289
      COG4586; ABC-type uncharacterized transport system, ATPase component [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43569.1

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