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    RBL2 Rbl2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854439, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RBL2
    Official Full Name
    Rbl2p
    Primary source
    SGD:S000005791
    Locus tag
    YOR265W
    See related
    AllianceGenome:SGD:S000005791; FungiDB:YOR265W; VEuPathDB:YOR265W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables beta-tubulin binding activity. Involved in tubulin complex assembly. Located in cytoplasm. Orthologous to human TBCA (tubulin folding cofactor A). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RBL2 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (820454..820774)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative GTPase GPN2 Neighboring gene Dse3p Neighboring gene Pnt1p Neighboring gene putative serine/threonine protein kinase HRK1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the post-chaperonin beta-tubulin binding cofactor Rbl2p. Steinbacher S. Nat Struct Biol, 1999 Nov. PMID 10542094
    2. Regulation of tubulin polypeptides and microtubule function: Luv1p [correction of Rki1p] interacts with the beta-tubulin binding protein Rbl2p. Smith AM, et al. Chromosoma, 1998 Dec. PMID 9914379
    3. Rbl2p, a yeast protein that binds to beta-tubulin and participates in microtubule function in vivo. Archer JE, et al. Cell, 1995 Aug 11. PMID 7634332
    4. Model for the yeast cofactor A-beta-tubulin complex based on computational docking and mutagensis. You L, et al. J Mol Biol, 2004 Aug 27. PMID 15321725
    5. Formation and function of the Rbl2p-beta-tubulin complex. Archer JE, et al. Mol Cell Biol, 1998 Mar. PMID 9488492, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables beta-tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-tubulin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tubulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in post-chaperonin tubulin folding pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tubulin complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tubulin complex assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tubulin complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rbl2p
    NP_014908.1
    • Protein involved in microtubule morphogenesis; required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      820454..820774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183684.1 → NP_014908.1  TPA: Rbl2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014908.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2W5, P48606
      UniProtKB/TrEMBL
      A6ZPA2, B3LJT2, C7GWC5, C8ZH16, G2WND2, N1NWW1
      Conserved Domains (1) summary
      pfam02970
      Location:6 → 92
      TBCA; Tubulin binding cofactor A
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48606.1

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