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    RTP1 Rtp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855223, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RTP1
    Official Full Name
    Rtp1p
    Primary source
    SGD:S000004797
    Locus tag
    YMR185W
    See related
    AllianceGenome:SGD:S000004797; FungiDB:YMR185W; VEuPathDB:YMR185W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein import into nucleus. Located in cytoplasm. Orthologous to human TANGO6 (transport and golgi organization 6 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RTP1 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (629025..631970)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene syntaxin Neighboring gene Add37p Neighboring gene Hsp90 family chaperone HSC82 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comprehensive and quantitative analysis of yeast deletion mutants defective in apical and isotropic bud growth. Watanabe M, et al. Curr Genet, 2009 Aug. PMID 19466415
    2. Different pathways for the nuclear import of yeast RNA polymerase II. Gómez-Navarro N, et al. Biochim Biophys Acta, 2015 Nov. PMID 26455955
    3. Rtp1p is a karyopherin-like protein required for RNA polymerase II biogenesis. Gómez-Navarro N, et al. Mol Cell Biol, 2013 May. PMID 23438601, Free PMC Article
    4. Large-scale functional genomic analysis of sporulation and meiosis in Saccharomyces cerevisiae. Enyenihi AH, et al. Genetics, 2003 Jan. PMID 12586695, Free PMC Article
    5. Essential histone chaperones collaborate to regulate transcription and chromatin integrity. Viktorovskaya O, et al. Genes Dev, 2021 May 1. PMID 33888559, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Rtp1p
    NP_013910.1
    • Protein required for the nuclear import and biogenesis of RNA pol II; conflicting evidence on whether null mutant is viable with elongated buds, or inviable; interacts with Rpb2, Rpb3, Nup116p, Nup100p and components of the R2TP complex (Rvb1p, Rvb2p, Pih1p); similar to human TMCO7 gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      629025..631970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182691.1 → NP_013910.1  TPA: Rtp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013910.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W009, Q12751
      UniProtKB/TrEMBL
      C7GTR5, N1P5R4
      Conserved Domains (2) summary
      pfam10304
      Location:947 → 979
      RTP1_C2; Required for nuclear transport of RNA pol II C-terminus 2
      pfam10363
      Location:735 → 840
      RTP1_C1; Required for nuclear transport of RNA pol II C-terminus 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12751.1

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