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    SPT21 Spt21p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855217, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SPT21
    Official Full Name
    Spt21p
    Primary source
    SGD:S000004791
    Locus tag
    YMR179W
    See related
    AllianceGenome:SGD:S000004791; FungiDB:YMR179W; VEuPathDB:YMR179W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in heterochromatin formation and regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SPT21 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (619858..622134)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Mmt1p Neighboring gene Fpy1p Neighboring gene polynucleotide 5'-phosphatase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The centromere and promoter factor, 1, CPF1, of Saccharomyces cerevisiae modulates gene activity through a family of factors including SPT21, RPD1 (SIN3), RPD3 and CCR4. McKenzie EA, et al. Mol Gen Genet, 1993 Sep. PMID 8413187
    2. The SPT10 and SPT21 genes of Saccharomyces cerevisiae. Natsoulis G, et al. Genetics, 1994 Jan. PMID 8138180, Free PMC Article
    3. Identification of genes affecting lipid content using transposon mutagenesis in Saccharomyces cerevisiae. Kamisaka Y, et al. Biosci Biotechnol Biochem, 2006 Mar. PMID 16556980
    4. Identification of Novel Components of Target-of-Rapamycin Signaling Pathway by Network-Based Multi-Omics Integrative Analysis. Dereli Eke E, et al. OMICS, 2019 May. PMID 30985253
    5. The Rad53(CHK1/CHK2)-Spt21(NPAT) and Tel1(ATM) axes couple glucose tolerance to histone dosage and subtelomeric silencing. Bruhn C, et al. Nat Commun, 2020 Aug 19. PMID 32814778, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Replication stress inhibits synthesis of histone mRNAs in yeast by removing Spt10p and Spt21p from the histone promoters.
      Title: Replication stress inhibits synthesis of histone mRNAs in yeast by removing Spt10p and Spt21p from the histone promoters.
    2. The Rad53(CHK1/CHK2)-Spt21(NPAT) and Tel1(ATM) axes couple glucose tolerance to histone dosage and subtelomeric silencing.
      Title: The Rad53(CHK1/CHK2)-Spt21(NPAT) and Tel1(ATM) axes couple glucose tolerance to histone dosage and subtelomeric silencing.
    3. Spt10 and Spt21 control silencing in S. cerevisiae by altering chromatin structure through roles beyond the control of histone gene expression.
      Title: Spt10 and Spt21 are required for transcriptional silencing in Saccharomyces cerevisiae.
    4. mutations lethal when combined with spt10 mutations
      Title: Evidence that Spt10 and Spt21 of Saccharomyces cerevisiae play distinct roles in vivo and functionally interact with MCB-binding factor, SCB-binding factor and Snf1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in rDNA heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in silent mating-type cassette heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in silent mating-type cassette heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    Spt21p
    NP_013904.1
    • Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; binds with Spt10p to histone gene promoters during S phase; localizes to nuclear foci that become diffuse upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      619858..622134
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182685.1 → NP_013904.1  TPA: Spt21p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013904.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W002, P35209
      UniProtKB/TrEMBL
      C8ZF42, N1NXH7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35209.1

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