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    APE3 aminopeptidase Y [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852589, updated on 9-Dec-2024

    Summary

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    Official Symbol
    APE3
    Official Full Name
    aminopeptidase Y
    Primary source
    SGD:S000000490
    Locus tag
    YBR286W
    See related
    AllianceGenome:SGD:S000000490; FungiDB:YBR286W; VEuPathDB:YBR286W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    APY1
    Summary
    Enables aminopeptidase activity. Involved in protein catabolic process in the vacuole. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See APE3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (774700..776313)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene metallo-dependent hydrolase superfamily protein Neighboring gene Hab1p Neighboring gene uncharacterized protein Neighboring gene Apm3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enhanced lysosomal activity by overexpressed aminopeptidase Y in Saccharomyces cerevisiae. Yoon J, et al. Mol Cell Biochem, 2016 Jun. PMID 27221740
    2. Aminopeptidase Y, a new aminopeptidase from Saccharomyces cerevisiae. Purification, properties, localization, and processing by protease B. Yasuhara T, et al. J Biol Chem, 1994 May 6. PMID 8175799
    3. Molecular cloning of the aminopeptidase Y gene of Saccharomyces cerevisiae. Sequence analysis and gene disruption of a new aminopeptidase. Nishizawa M, et al. J Biol Chem, 1994 May 6. PMID 8175800
    4. Regulation of the yeast vacuolar aminopeptidase Y gene (APY1) expression. Herrera-Camacho I, et al. FEMS Microbiol Lett, 1996 Jun 1. PMID 8674980
    5. A yeast Golgi E-type ATPase with an unusual membrane topology. Zhong X, et al. J Biol Chem, 1999 Nov 12. PMID 10551827

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloexopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein catabolic process in the vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aminopeptidase Y
    NP_009845.2
    • Vacuolar aminopeptidase Y; processed to mature form by Prb1p; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      774700..776313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178634.1 → NP_009845.2  TPA: aminopeptidase Y [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009845.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQT1, P37302, P38154
      UniProtKB/TrEMBL
      B3LMM7, C7GMU6, D3UF33, N1P9N7
      Conserved Domains (2) summary
      cd02130
      Location:155 → 284
      PA_ScAPY_like; Protease-associated domain containing proteins like Saccharomyces cerevisiae aminopeptidase Y (ScAPY). This group contains various PA domain-containing proteins similar to the S. cerevisiae APY, including Trichophyton rubrum leucine aminopeptidase 1(LAP1) ...
      cd03876
      Location:78 → 506
      M28_SGAP_like; M28 Zn-peptidase Streptomyces griseus aminopeptidase and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37302.1

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