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    RPP1 RNA-binding RNA processing protein RPP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856459, updated on 9-Dec-2024

    Summary

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    Official Symbol
    RPP1
    Official Full Name
    RNA-binding RNA processing protein RPP1
    Primary source
    SGD:S000001104
    Locus tag
    YHR062C
    See related
    AllianceGenome:SGD:S000001104; FungiDB:YHR062C; VEuPathDB:YHR062C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Contributes to ribonuclease MRP activity and ribonuclease P activity. Involved in RNA metabolic process. Located in cytosol and nucleus. Part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Orthologous to human RPP30 (ribonuclease P/MRP subunit p30). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See RPP1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (222877..223758, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Vma22p Neighboring gene Gic1p Neighboring gene 2-dehydropantoate 2-reductase PAN5 Neighboring gene Ssz1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae. Stolc V, et al. Genes Dev, 1997 Sep 15. PMID 9308968, Free PMC Article
    2. GAMETOPHYTE DEFECTIVE 1, a putative subunit of RNases P/MRP, is essential for female gametogenesis and male competence in Arabidopsis. Wang SQ, et al. PLoS One, 2012. PMID 22509260, Free PMC Article
    3. Rpp1, an essential protein subunit of nuclear RNase P required for processing of precursor tRNA and 35S precursor rRNA in Saccharomyces cerevisiae. Stolc V, et al. Genes Dev, 1997 Nov 1. PMID 9353260, Free PMC Article
    4. Rpp2, an essential protein subunit of nuclear RNase P, is required for processing of precursor tRNAs and 35S precursor rRNA in Saccharomyces cerevisiae. Stolc V, et al. Proc Natl Acad Sci U S A, 1998 Jun 9. PMID 9618478, Free PMC Article
    5. Conserved regions of ribonucleoprotein ribonuclease MRP are involved in interactions with its substrate. Esakova O, et al. Nucleic Acids Res, 2013 Aug. PMID 23700311, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ribonuclease MRP activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ribonuclease P activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ribonuclease P activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in intronic box C/D snoRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear-transcribed mRNA catabolic process, RNase MRP-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleolar ribonuclease P complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleolar ribonuclease P complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nucleolar ribonuclease P complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonuclease MRP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonuclease MRP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA-binding RNA processing protein RPP1
    NP_011929.1
    • Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      222877..223758 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179192.1 → NP_011929.1  TPA: RNA-binding RNA processing protein RPP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011929.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL11, P38786
      UniProtKB/TrEMBL
      A6ZSW8, B3LSI1, B5VJZ0, C7GTX1, C8Z9J9, G2WFD4, N1P110
      Conserved Domains (1) summary
      pfam01876
      Location:3 → 227
      RNase_P_p30; RNase P subunit p30
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38786.1

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