Dtx1 deltex 1, E3 ubiquitin ligase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dtx1provided by MGI
Official Full Name: deltex 1, E3 ubiquitin ligaseprovided by MGI
Primary source: MGI:MGI:1352744
See related: Ensembl:ENSMUSG00000029603 AllianceGenome:MGI:1352744
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fxit1; mKIAA4160
Summary: Predicted to enable Notch binding activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Acts upstream of or within several processes, including Notch signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of T cell differentiation. Predicted to be located in cytosol and nuclear body. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human DTX1 (deltex E3 ubiquitin ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 82.7), CNS E18 (RPKM 30.0) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 60.64 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (120818268..120850879, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (120680203..120711867, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-210-3p Impairs Pancreatic beta-Cell Function by Targeting Dtx1 in Gestational Diabetes Mellitus.
Title: miR-210-3p Impairs Pancreatic β-Cell Function by Targeting Dtx1 in Gestational Diabetes Mellitus.
exerts one level of control on regulatory T-cell stability by sustaining the expression of Foxp3 protein
Title: Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo.
DTX1, similar to Cbl-b and Itch, participates in T cell anergy-induced PKC-theta degradation. there is a coupling of DTX1 to Cbl-b in T cell anergy.
Title: Deltex1 promotes protein kinase Cθ degradation and sustains Casitas B-lineage lymphoma expression.
Data show that Deltex1 ablation enabled Id1-expressing progenitors to differentiate to the DN3 (CD44(-) CD25(+)) stage, which was accompanied by enhanced Notch1 expression in T-cell progenitors.
Title: Id1 attenuates Notch signaling and impairs T-cell commitment by elevating Deltex1 expression.
deficiency of DTX1 augmented T cell activation, conferred resistance to anergy induction, enhanced autoantibody generation, and increased inflammation
Title: Deltex1 is a target of the transcription factor NFAT that promotes T cell anergy.
Deltex can act as a negative regulator of Notch signals in T cells but that endogenous levels of Deltex1 and Deltex2 are not important for regulating Notch signals during thymocyte development[Deltex1]
Title: T cells develop normally in the absence of both Deltex1 and Deltex2.
Deltex selectively suppresses T-cell activation through degradation of a key signaling molecule, MEKK1.
Title: Deltex regulates T-cell activation by targeted degradation of active MEKK1.
NB-3/Notch1 pathway promotes neural progenitor cell differentiation into
Title: NB-3/Notch1 pathway via Deltex1 promotes neural progenitor cell differentiation into oligodendrocytes.
Deltex-1 ubiquitin ligase activity is dispensable for mouse development and immune function.
Title: Normal immune system development in mice lacking the Deltex-1 RING finger domain.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235295

UniSTS:465452 (e-PCR)
- UniSTS:465452

Dtx1 (e-PCR), detects polymorphism
- UniSTS:465452

Dtx1 (e-PCR), detects polymorphism
- UniSTS:465453

Dtx1 (e-PCR), detects polymorphism
- UniSTS:499088

AW556360 (e-PCR)
- UniSTS:207868

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Notch binding	IEA Inferred from Electronic Annotation more info
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables SH3 domain binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase DTX1

Names: FXI-T1; RING-type E3 ubiquitin transferase DTX1; deltex 1 homolog; deltex1; fractionated x-irradiation induced transcript 1; mDTX1; protein deltex-1

NP_001404401.1

EC 2.3.2.27

NP_001404402.1

EC 2.3.2.27

NP_001404403.1

EC 2.3.2.27

NP_032078.2

EC 2.3.2.27

XP_011246483.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417472.1 → NP_001404401.1 E3 ubiquitin-protein ligase DTX1 isoform a

Status: VALIDATED

Source sequence(s)

AC115937, AC125183
NM_001417473.1 → NP_001404402.1 E3 ubiquitin-protein ligase DTX1 isoform b

Status: VALIDATED

Source sequence(s)

AC115937, AC125183

UniProtKB/Swiss-Prot

Q3TER5, Q61010, Q8C2H2, Q9ER09
NM_001417474.1 → NP_001404403.1 E3 ubiquitin-protein ligase DTX1 isoform b

Status: VALIDATED

Source sequence(s)

AC125183

UniProtKB/Swiss-Prot

Q3TER5, Q61010, Q8C2H2, Q9ER09
NM_008052.4 → NP_032078.2 E3 ubiquitin-protein ligase DTX1 isoform b

See identical proteins and their annotated locations for NP_032078.2

Status: VALIDATED

Source sequence(s)

AC115937, AC125183

Consensus CDS

CCDS19624.1

UniProtKB/Swiss-Prot

Q3TER5, Q61010, Q8C2H2, Q9ER09

UniProtKB/TrEMBL

Q5DTK6

Related

ENSMUSP00000031607.7, ENSMUST00000031607.7

Conserved Domains (3) summary

smart00678
Location:26 → 102

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16671
Location:415 → 483

RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins

pfam18102
Location:486 → 620

DTC; Deltex C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

120818268..120850879 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011248181.4 → XP_011246483.1 E3 ubiquitin-protein ligase DTX1 isoform X1

See identical proteins and their annotated locations for XP_011246483.1

UniProtKB/TrEMBL

Q5DTK6

Conserved Domains (3) summary

smart00678
Location:26 → 102

WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis

cd16671
Location:415 → 487

RING-H2_DTX1_4; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase deltex1 (DTX1), deltex4 (DTX4), and similar proteins

pfam18102
Location:490 → 624

DTC; Deltex C-terminal domain